Omecron
Generic Name
Omeprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| omecron 40 mg capsule | ৳ 8.02 | ৳ 80.20 |
Description
Overview of the medicine
Omecron 40 mg Capsule contains Omeprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
GERD: 20-40 mg once daily for 4-8 weeks. Peptic Ulcers: 20-40 mg once daily for 2-4 weeks (duodenal) or 4-8 weeks (gastric). Zollinger-Ellison Syndrome: Initial dose 60 mg once daily, adjusted as per patient response.
Elderly
No specific dosage adjustment is generally required for elderly patients, but caution is advised in those with severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take Omecron 40 mg Capsule orally, usually once daily in the morning, at least 30 minutes before a meal. Swallow the capsule whole with water; do not crush or chew it.
Mechanism of Action
Omeprazole works by irreversibly binding to the H+/K+-ATPase enzyme (the proton pump) in the gastric parietal cells. This inhibits the final step in gastric acid secretion, thereby reducing acid levels in the stomach.
Pharmacokinetics
Onset
Acid inhibitory effect starts within 1-2 hours, with maximal effect seen within 2 hours.
Excretion
Approximately 77% of the dose is excreted as metabolites in the urine, and the remainder in the feces.
Half life
Plasma elimination half-life is short, about 0.5-1 hour, but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed from the gastrointestinal tract, though subject to extensive first-pass metabolism. Bioavailability is approximately 30-40% for the first dose.
Metabolism
Extensively metabolized in the liver primarily by the cytochrome P450 enzyme system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to omeprazole or any component of the formulation
- •Co-administration with nelfinavir
Drug Interactions
Warfarin
Increased risk of bleeding due to inhibition of warfarin metabolism.
Tacrolimus
Increased plasma levels of tacrolimus.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of its activation.
Methotrexate
Increased plasma levels of methotrexate, potentially leading to toxicity.
Nelfinavir/Atazanavir
Decreased plasma levels and efficacy of these antiretroviral drugs.
Storage
Store below 30°C in a dry and cool place. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, no specific antidote is known. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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