Onasia
Generic Name
Onasia
Manufacturer
Acme Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| onasia 4 mg oral solution | ৳ 45.14 | N/A |
Description
Overview of the medicine
Onasia 4 mg Oral Solution is an antiemetic used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin, a natural substance in the body that can cause nausea and vomiting.
Uses & Indications
Dosage
Adults
Typically 8 mg orally 30 minutes before chemotherapy, then 8 mg every 8 hours for up to 5 days. For other indications, dose varies.
Elderly
No dosage adjustment generally required. Patients over 75 years may require adjustment based on individual response.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment.
How to Take
For oral solution, measure the prescribed dose using the provided dosing syringe or spoon. It can be taken with or without food.
Mechanism of Action
Onasia selectively antagonizes the 5-HT3 receptor, located peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. This action blocks serotonin's ability to stimulate the vomiting reflex.
Pharmacokinetics
Onset
Within 30 minutes to 2 hours.
Excretion
Approximately 5-10% excreted unchanged in urine; remainder excreted as metabolites in urine and feces.
Half life
Approximately 3-6 hours in adults.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract; peak plasma concentrations reached within 1.5 hours.
Metabolism
Extensively metabolized in the liver by hydroxylation, followed by glucuronide or sulfate conjugation. CYP3A4, CYP2D6, and CYP1A2 enzymes are involved.
Side Effects
Contraindications
- Hypersensitivity to Onasia or any component of the formulation
- Concomitant use with apomorphine
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease Onasia plasma concentrations by inducing hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include visual disturbances, severe constipation, hypotension, and vasovagal episodes. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the benefit outweighs the potential risk to the fetus. It is unknown whether Onasia is excreted in human milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to Onasia or any component of the formulation
- Concomitant use with apomorphine
Drug Interactions
Tramadol
May reduce the analgesic effect of tramadol.
Apomorphine
Concomitant use is contraindicated due to reports of profound hypotension and loss of consciousness.
Phenytoin, Carbamazepine, Rifampicin
May decrease Onasia plasma concentrations by inducing hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light. Do not freeze. Keep out of reach of children.
Overdose
Symptoms include visual disturbances, severe constipation, hypotension, and vasovagal episodes. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and the benefit outweighs the potential risk to the fetus. It is unknown whether Onasia is excreted in human milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date (unopened). Use within 28 days after opening.
Availability
Pharmacies nationwide, hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available, patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated Onasia's efficacy and safety in preventing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). Studies confirm its selective 5-HT3 receptor antagonist activity.
Lab Monitoring
- No routine laboratory monitoring is typically required. ECG monitoring may be considered in patients with underlying cardiac conditions or those on concomitant QT-prolonging drugs.
Doctor Notes
- Counsel patients on correct measurement of oral solution dose.
- Be aware of potential QT prolongation, especially in patients with pre-existing cardiac conditions or those on other QT-prolonging medications.
- Monitor for signs of serotonin syndrome if used concomitantly with other serotonergic drugs.
Patient Guidelines
- Take Onasia exactly as prescribed by your doctor.
- Do not exceed the recommended dose.
- Report any unusual side effects to your doctor immediately.
- Do not stop taking the medicine without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Onasia may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid strong odors that can trigger nausea.
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