Adults

Adult dosage typically uses higher strength formulations. If this suspension is used, the equivalent dose would be higher (e.g., 250-500mg Amoxicillin equivalent).

Children

For children 3 months to 12 years (based on Amoxicillin component): 20 mg/kg/day for mild to moderate infections in 3 divided doses. For severe infections: 40 mg/kg/day in 3 divided doses. (e.g., 5ml of 125mg/31.25mg suspension three times daily for a 10kg child).

Renal_impairment

Dose adjustment required based on creatinine clearance for both children and adults. Consult prescribing information for specific guidelines.

Onset

Typically within 1 hour.

Excretion

Primarily excreted unchanged by the kidneys (glomerular filtration and tubular secretion) for Amoxicillin. Clavulanic acid is also excreted by the kidneys and via non-renal mechanisms.

Half life

Approximately 1 to 1.5 hours for both components.

Absorption

Both Amoxicillin and Clavulanic Acid are well absorbed after oral administration. Absorption is not significantly affected by food.

Metabolism

Amoxicillin is partially metabolized to inactive penicilloic acid. Clavulanic acid is extensively metabolized.

Probenecid

Increases Amoxicillin levels by decreasing renal tubular secretion.

Allopurinol

Increased risk of rash with Amoxicillin.

Methotrexate

Increases methotrexate toxicity due to reduced renal clearance.

Oral contraceptives

May reduce efficacy of oral contraceptives (rarely significant).

Oral anticoagulants (e.g., Warfarin)

May prolong prothrombin time; monitor INR closely.