Adults

Apply a small amount (approximately 1 cm strip) into the conjunctival sac of the affected eye(s) 2-3 times daily for 7-10 days, or as directed by a physician. Continue for at least 48 hours after signs and symptoms of infection resolve.

Elderly

No specific dose adjustment is required for elderly patients. The dosage is the same as for adults.

Renal_impairment

Not applicable, as systemic absorption is minimal and renal excretion is not a primary elimination route for topical ocular application.

Onset

Therapeutic concentrations in ocular tissues are achieved rapidly, typically within 1-2 hours of application. Clinical improvement may be observed within 24-48 hours.

Excretion

The majority of the applied dose is cleared from the ocular surface through tear drainage. Any minimally absorbed drug is excreted via renal and/or hepatic routes.

Half life

Due to minimal systemic absorption, a systemic half-life is not clinically relevant or accurately determined for topical ophthalmic use. The drug primarily acts locally.

Absorption

Minimal systemic absorption occurs following topical ocular administration, limiting systemic exposure and associated risks. High concentrations are achieved locally in ocular tissues.

Metabolism

Systemic metabolism is negligible due to very low systemic absorption. Any absorbed drug is likely metabolized via typical hepatic pathways.

Other Ophthalmic Preparations

If using multiple topical ophthalmic medications, administer them at least 5 minutes apart. Apply the ointment last.