Optison-N
Generic Name
Naphazoline Hydrochloride + Pheniramine Maleate Eye Drop
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| optison n 01 05 eye drop | ৳ 30.41 | N/A |
Description
Overview of the medicine
Optison-N Eye Drop is a combination medication used to relieve eye redness, itching, and irritation associated with allergic conjunctivitis.
Uses & Indications
Dosage
Adults
Instill 1 to 2 drops in the affected eye(s) up to 4 times a day, or as directed by a physician.
Elderly
No specific dosage adjustment is generally required for elderly patients. Use as per adult dosage.
Renal_impairment
No dosage adjustment is necessary due to minimal systemic absorption.
How to Take
For ophthalmic use only. Tilt head back, pull down the lower eyelid, and instill the drops into the conjunctival sac. Avoid touching the dropper tip to the eye or any other surface.
Mechanism of Action
Naphazoline acts as a vasoconstrictor, reducing ocular redness. Pheniramine is an antihistamine that blocks histamine receptors, thereby reducing itching, swelling, and tearing.
Pharmacokinetics
Onset
Rapid, typically within minutes.
Excretion
Systemic excretion is negligible due to minimal absorption.
Half life
Not significant systemically due to minimal absorption.
Absorption
Minimal systemic absorption occurs following ophthalmic administration. Primarily acts locally.
Metabolism
Primarily local metabolism; systemic metabolism is negligible.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with narrow-angle glaucoma.
Drug Interactions
Other Ophthalmic Decongestants
Concomitant use may increase the risk of adverse effects like rebound hyperemia.
Monoamine Oxidase Inhibitors (MAOIs)
Use with caution. There is a risk of hypertensive crisis if significant systemic absorption occurs.
Storage
Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze.
Overdose
Overdose may lead to increased local irritation. If significant systemic absorption occurs, symptoms such as drowsiness, bradycardia, hypotension, or CNS depression may manifest. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a physician.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation.
- Patients with narrow-angle glaucoma.
Drug Interactions
Other Ophthalmic Decongestants
Concomitant use may increase the risk of adverse effects like rebound hyperemia.
Monoamine Oxidase Inhibitors (MAOIs)
Use with caution. There is a risk of hypertensive crisis if significant systemic absorption occurs.
Storage
Store at room temperature (15-30°C). Protect from light and moisture. Do not freeze.
Overdose
Overdose may lead to increased local irritation. If significant systemic absorption occurs, symptoms such as drowsiness, bradycardia, hypotension, or CNS depression may manifest. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if clearly needed and the potential benefits outweigh the potential risks. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 1-2 years unopened. Discard 1 month after opening.
Availability
Available in pharmacies
Approval Status
DGDA Approved (Bangladesh)
Patent Status
Off-patent
Clinical Trials
This combination is well-established, and its efficacy and safety are supported by numerous historical clinical studies.
Lab Monitoring
- No routine laboratory monitoring is typically required for ophthalmic use.
Doctor Notes
- Advise patients on proper instillation technique to avoid contamination and maximize efficacy.
- Caution patients about potential rebound redness with overuse.
- Screen for narrow-angle glaucoma before recommending.
Patient Guidelines
- Remove contact lenses before use and wait at least 15 minutes before reinserting.
- Do not touch the dropper tip to any surface to avoid contamination.
- Wait at least 5 minutes before administering other ophthalmic medications.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or pupil dilation. Patients should be cautioned against driving or operating machinery until vision is clear.
Lifestyle Advice
- Avoid exposure to known allergens that trigger allergic conjunctivitis.
- Maintain good eye hygiene to prevent infections.
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