Orabis
Generic Name
Deflazacort
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orabis 25 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Orabis 25 mg tablet contains Deflazacort, a corticosteroid used to treat various inflammatory and autoimmune conditions, including rheumatic disorders, asthma, allergies, and certain kidney diseases.
Uses & Indications
Dosage
Adults
Initial dose typically 6-90 mg daily, adjusted according to response. Duchenne muscular dystrophy: 0.9 mg/kg/day.
Elderly
No specific dose adjustment required, but use with caution due to potential comorbidities and polypharmacy.
Renal_impairment
No dose adjustment needed for renal impairment. Use with caution in severe renal impairment due to potential fluid retention.
How to Take
Take orally, preferably with food to minimize gastrointestinal upset. Do not stop abruptly; taper dose gradually.
Mechanism of Action
Deflazacort is a glucocorticoid that binds to specific intracellular glucocorticoid receptors. This complex then translocates into the nucleus, where it modulates gene expression, leading to anti-inflammatory and immunosuppressive effects. It reduces inflammation by inhibiting the release of inflammatory mediators and suppressing immune responses.
Pharmacokinetics
Onset
Anti-inflammatory effects typically begin within a few hours, full therapeutic effect may take several days.
Excretion
Mainly excreted in urine (about 70%) and feces (about 30%) as metabolites.
Half life
The active metabolite has a plasma half-life of approximately 1.5-2 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, converted to its active metabolite (21-desacetyl deflazacort). Peak plasma concentrations of the active metabolite are achieved within 1.5-2 hours.
Metabolism
Extensively metabolized in the liver to the active metabolite, 21-desacetyl deflazacort, which is then further metabolized.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any excipients
- Live virus vaccines during corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Anticoagulants
May alter anticoagulant effects; monitor INR.
CYP3A4 inducers (e.g., rifampicin)
May decrease deflazacort levels, reducing efficacy.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase deflazacort levels, requiring dose adjustment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Excreted in breast milk; caution advised, weigh risks vs benefits.
Side Effects
Contraindications
- Systemic fungal infections
- Hypersensitivity to deflazacort or any excipients
- Live virus vaccines during corticosteroid therapy
Drug Interactions
NSAIDs
Increased risk of gastrointestinal ulceration.
Anticoagulants
May alter anticoagulant effects; monitor INR.
CYP3A4 inducers (e.g., rifampicin)
May decrease deflazacort levels, reducing efficacy.
CYP3A4 inhibitors (e.g., ketoconazole)
May increase deflazacort levels, requiring dose adjustment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include exaggeration of known side effects. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Excreted in breast milk; caution advised, weigh risks vs benefits.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Available in pharmacies worldwide
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available, original patent expired
Clinical Trials
Deflazacort has undergone extensive clinical trials demonstrating its efficacy in various inflammatory and autoimmune conditions, as well as Duchenne muscular dystrophy. Ongoing research continues to explore its applications and long-term effects.
Lab Monitoring
- Blood glucose levels
- Blood pressure
- Electrolytes
- Bone density (with long-term use)
- Ophthalmological exams (with long-term use)
Doctor Notes
- Careful dose titration and gradual withdrawal are crucial to minimize adverse effects.
- Monitor patients for signs of infection, hyperglycemia, and hypertension.
- Consider bone protection strategies for long-term users.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking this medicine suddenly without consulting your doctor, as it can cause withdrawal symptoms.
- Report any unusual side effects or signs of infection to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Deflazacort may cause dizziness or visual disturbances in some patients. Exercise caution when driving or operating machinery until you know how it affects you.
Lifestyle Advice
- Maintain a balanced diet to manage weight gain and bone health.
- Engage in regular, moderate exercise if possible.
- Avoid exposure to people with infections, especially chickenpox or measles.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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