Orabis
Generic Name
orabis-5-mg-tablet
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| orabis 5 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Orabis 5 mg tablet contains Desloratadine, a non-drowsy antihistamine used to relieve symptoms associated with seasonal and perennial allergic rhinitis, and chronic idiopathic urticaria.
Uses & Indications
Dosage
Adults
5 mg once daily.
Elderly
No dosage adjustment generally required; however, caution should be exercised in patients with renal or hepatic impairment.
Renal_impairment
For patients with severe renal impairment (creatinine clearance < 30 mL/min), a reduced starting dose of 5 mg every other day is recommended.
How to Take
Orabis tablet can be taken with or without food. Swallow the tablet whole with water.
Mechanism of Action
Desloratadine is a potent, long-acting, selective peripheral H1-receptor antagonist. It inhibits the release of histamine from mast cells and basophils, and blocks the histamine-mediated effects, thereby reducing allergy symptoms.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Excreted in urine and feces as metabolites.
Half life
Approximately 27 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations achieved in approximately 3 hours.
Metabolism
Extensively metabolized to 3-hydroxydesloratadine, an active metabolite, primarily by CYP2C8.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
- Patients with phenylketonuria (due to aspartame in some formulations, though not typically in tablets).
Drug Interactions
Cimetidine
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Fluoxetine
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Erythromycin
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Ketoconazole
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Desloratadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk, therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Side Effects
Contraindications
- Hypersensitivity to Desloratadine, Loratadine, or any component of the formulation.
- Patients with phenylketonuria (due to aspartame in some formulations, though not typically in tablets).
Drug Interactions
Cimetidine
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Fluoxetine
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Erythromycin
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Ketoconazole
Coadministration with desloratadine may increase desloratadine plasma levels; however, no clinically relevant adverse events were reported.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, tachycardia, and headache. In the event of an overdose, symptomatic and supportive treatment is recommended. Desloratadine is not eliminated by hemodialysis.
Pregnancy & Lactation
Pregnancy Category C. Desloratadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk, therefore, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
Clinical Trials
Desloratadine has undergone extensive clinical trials demonstrating its efficacy and safety for allergic rhinitis and chronic idiopathic urticaria across various patient populations.
Lab Monitoring
- No routine lab monitoring is generally required. In patients with hepatic or renal impairment, liver function tests and renal function tests may be monitored if clinically indicated.
Doctor Notes
- Advise patients that while generally non-sedating, individual responses can vary.
- Review renal and hepatic function in elderly patients or those with pre-existing impairment.
- Caution about potential for enhanced CNS depression if consumed with alcohol or other sedatives.
Patient Guidelines
- Take Orabis tablet once daily as directed by your doctor.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Orabis is generally considered non-drowsy. However, individual responses may vary. If you experience dizziness or drowsiness, avoid driving or operating machinery.
Lifestyle Advice
- Avoid known allergens to help manage allergy symptoms.
- Maintain good hydration.
- Avoid alcohol consumption while taking this medication as it may enhance CNS depressant effects.
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Global Brand Names
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