Oriham
Generic Name
Omeprazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oriham 10 mg capsule | ৳ 8.00 | ৳ 80.00 |
Description
Overview of the medicine
Oriham (Omeprazole) is a proton pump inhibitor (PPI) used to reduce stomach acid production. It is prescribed for conditions such as gastroesophageal reflux disease (GERD), stomach ulcers, duodenal ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily for 4-8 weeks for GERD and ulcers. For Zollinger-Ellison syndrome, 60 mg once daily, adjusted as needed. H. pylori eradication usually involves 20 mg twice daily with antibiotics.
Elderly
No specific dose adjustment is generally required, but caution is advised due to potential age-related decrease in renal and hepatic function.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function.
How to Take
Take capsule whole with water, preferably in the morning before a meal. Do not chew or crush. If swallowing is difficult, the capsule may be opened and the contents mixed with a small amount of fruit juice or yogurt and swallowed immediately.
Mechanism of Action
Omeprazole works by irreversibly binding to and inhibiting the H+/K+-ATPase proton pump in the gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression within 1 hour, maximal effect within 2 hours.
Excretion
Mainly excreted in the urine (about 80%) and feces (about 20%) as metabolites.
Half life
0.5-1 hour (plasma elimination half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly but variably absorbed from the gastrointestinal tract; bioavailability is about 30-40% but increases with repeated administration. Peak plasma concentrations are reached within 0.5-3.5 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Increased plasma concentrations of diazepam due to inhibition of hepatic metabolism.
Warfarin
Increased INR and prothrombin time; monitor closely.
Tacrolimus
Increased plasma concentrations of tacrolimus.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased plasma levels of methotrexate, particularly at high doses.
Storage
Store in a cool, dry place, protected from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Symptoms of overdose are usually mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. It is excreted in human milk; use with caution in nursing mothers.
Side Effects
Contraindications
- Hypersensitivity to omeprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with nelfinavir.
Drug Interactions
Diazepam
Increased plasma concentrations of diazepam due to inhibition of hepatic metabolism.
Warfarin
Increased INR and prothrombin time; monitor closely.
Tacrolimus
Increased plasma concentrations of tacrolimus.
Clopidogrel
Reduced antiplatelet effect of clopidogrel due to inhibition of CYP2C19.
Methotrexate
Increased plasma levels of methotrexate, particularly at high doses.
Storage
Store in a cool, dry place, protected from light and moisture, below 30°C. Keep out of reach of children.
Overdose
Symptoms of overdose are usually mild and reversible, including nausea, vomiting, dizziness, abdominal pain, diarrhea, and headache. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the potential risk to the fetus. It is excreted in human milk; use with caution in nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies nationwide in Bangladesh
Approval Status
Approved by DGDA
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various acid-related disorders. Ongoing research continues to explore its full therapeutic potential and long-term effects.
Lab Monitoring
- Magnesium levels (for long-term use, especially with diuretics)
- Bone mineral density (for long-term use)
- Vitamin B12 levels (for long-term use)
Doctor Notes
- Consider the lowest effective dose for the shortest possible duration.
- Periodically reassess the need for continued PPI therapy.
- Be aware of potential drug interactions, especially with antiplatelets and antivirals.
Patient Guidelines
- Take as prescribed by your doctor.
- Inform your doctor about all other medications you are taking.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
Omeprazole usually does not affect the ability to drive or operate machinery. However, if side effects like dizziness or visual disturbances occur, caution is advised.
Lifestyle Advice
- Avoid spicy and fatty foods.
- Limit alcohol and caffeine intake.
- Elevate the head of your bed to reduce nighttime reflux.
- Eat smaller, more frequent meals.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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