Ornova
Generic Name
Olanzapine
Manufacturer
Local Pharmaceutical Co.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ornova 10 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Ornova 10mg Tablet contains Olanzapine, an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initial 5-10 mg once daily, target dose 10 mg/day. Max 20 mg/day. Bipolar Mania: Initial 10-15 mg once daily, target dose 15 mg/day. Max 20 mg/day.
Elderly
Lower starting dose (e.g., 5 mg/day) and slower titration, especially if other risk factors are present. Closely monitor for orthostatic hypotension.
Renal_impairment
No routine dosage adjustment required, but caution advised due to limited experience in severe renal impairment. Careful monitoring is recommended.
How to Take
Take orally once daily, with or without food. Do not crush or chew the tablet. Swallow whole.
Mechanism of Action
Olanzapine is a potent antagonist of serotonin 5-HT2A and dopamine D1, D2, D4 receptors. It also binds to muscarinic M1-M5, adrenergic α1, and histamine H1 receptors. Its antipsychotic effect is thought to be mediated through a combination of dopamine and serotonin receptor antagonism.
Pharmacokinetics
Onset
Clinical response typically observed within days to weeks for acute symptoms; maintenance treatment requires continuous therapy.
Excretion
Primarily renal excretion (60% as metabolites); about 30% excreted in feces.
Half life
Approximately 21-54 hours (mean 33 hours).
Absorption
Well absorbed orally, reaching peak plasma concentrations in 5-8 hours. Food does not significantly affect the rate or extent of absorption.
Metabolism
Extensively metabolized in the liver primarily by direct glucuronidation and by cytochrome P450-mediated oxidation (CYP1A2 and CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to olanzapine or any component of the formulation.
- Patients with known narrow-angle glaucoma.
Drug Interactions
Fluoxetine
May increase olanzapine concentration.
Antihypertensives
Increased risk of orthostatic hypotension.
Carbamazepine, Rifampin
May decrease olanzapine levels (CYP1A2 inducers).
Alcohol, CNS depressants
Enhanced sedative effects.
Fluvoxamine, Ciprofloxacin
May increase olanzapine levels (CYP1A2 inhibitors).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, slurred speech, tachycardia, extrapyramidal symptoms, and respiratory depression. Management is symptomatic and supportive, including maintaining an open airway, oxygenation, and ventilation. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Neonates exposed to antipsychotics during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Olanzapine is excreted in human milk; breastfeeding is not recommended.
Side Effects
Contraindications
- Hypersensitivity to olanzapine or any component of the formulation.
- Patients with known narrow-angle glaucoma.
Drug Interactions
Fluoxetine
May increase olanzapine concentration.
Antihypertensives
Increased risk of orthostatic hypotension.
Carbamazepine, Rifampin
May decrease olanzapine levels (CYP1A2 inducers).
Alcohol, CNS depressants
Enhanced sedative effects.
Fluvoxamine, Ciprofloxacin
May increase olanzapine levels (CYP1A2 inhibitors).
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, slurred speech, tachycardia, extrapyramidal symptoms, and respiratory depression. Management is symptomatic and supportive, including maintaining an open airway, oxygenation, and ventilation. Activated charcoal may be useful.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs potential risk to the fetus. Neonates exposed to antipsychotics during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms. Olanzapine is excreted in human milk; breastfeeding is not recommended.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture, depending on the manufacturer.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies globally
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of olanzapine in the treatment of schizophrenia and bipolar disorder. These trials have evaluated its impact on symptom reduction, relapse prevention, and quality of life.
Lab Monitoring
- Fasting blood glucose (due to risk of hyperglycemia/diabetes)
- Lipid profile (due to risk of dyslipidemia)
- Weight/BMI (due to risk of weight gain)
- Liver function tests (baseline and periodically)
- Blood pressure
- Cardiac monitoring (ECG) if cardiovascular risk factors present
Doctor Notes
- Monitor for metabolic side effects including weight, fasting glucose, and lipid profile at baseline and periodically during treatment.
- Counsel patients on the risk of Neuroleptic Malignant Syndrome (NMS) and tardive dyskinesia.
- Not indicated for the treatment of dementia-related psychosis due to increased mortality risk.
Patient Guidelines
- Take the medicine exactly as prescribed; do not stop abruptly without consulting your doctor.
- Report any unusual side effects immediately, especially fever, muscle rigidity, confusion (signs of NMS).
- Monitor your weight and blood sugar regularly as advised by your doctor.
- Avoid alcohol and other CNS depressants while taking this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause drowsiness or dizziness, especially at the beginning of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to manage potential weight gain.
- Avoid smoking, as it can reduce olanzapine levels and effectiveness.
- Attend all scheduled medical appointments and follow-ups.
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