Ornova
Generic Name
Rabeprazole Sodium
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ornova 20 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Rabeprazole is a proton pump inhibitor (PPI) used to treat conditions involving excessive stomach acid, such as gastroesophageal reflux disease (GERD) and peptic ulcers.
Uses & Indications
Dosage
Adults
For GERD and ulcers: 20 mg once daily, usually in the morning before food. For H. pylori eradication: 20 mg twice daily in combination with antibiotics.
Elderly
No specific dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Take orally, swallowed whole, typically once daily in the morning before breakfast. Do not crush, chew, or split the tablet.
Mechanism of Action
Rabeprazole irreversibly blocks the hydrogen-potassium ATPase enzyme system (proton pump) in gastric parietal cells, thereby reducing gastric acid secretion.
Pharmacokinetics
Onset
Acid secretion inhibition begins within 1 hour.
Excretion
Approximately 90% is excreted renally, and 10% in feces.
Half life
Approximately 1 to 2 hours.
Absorption
Rapidly absorbed, bioavailability is approximately 52%.
Metabolism
Primarily hepatic metabolism via cytochrome P450 system (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to Rabeprazole, other proton pump inhibitors, or any component of the formulation.
- Known allergic reactions to benzimidazole derivatives.
Drug Interactions
Digoxin
May increase digoxin levels, monitor levels.
Warfarin
May increase INR and prothrombin time, monitor carefully.
Clopidogrel
Reduced antiplatelet effect, though less significant than with omeprazole.
Methotrexate
May increase methotrexate levels, especially with high doses.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. Management of overdose should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no risk, but human data is limited. Use only if clearly needed. Not recommended during breastfeeding as it may be excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to Rabeprazole, other proton pump inhibitors, or any component of the formulation.
- Known allergic reactions to benzimidazole derivatives.
Drug Interactions
Digoxin
May increase digoxin levels, monitor levels.
Warfarin
May increase INR and prothrombin time, monitor carefully.
Clopidogrel
Reduced antiplatelet effect, though less significant than with omeprazole.
Methotrexate
May increase methotrexate levels, especially with high doses.
Storage
Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. Management of overdose should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no risk, but human data is limited. Use only if clearly needed. Not recommended during breastfeeding as it may be excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Rabeprazole has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of GERD, peptic ulcers, and H. pylori eradication.
Lab Monitoring
- For long-term use (over 3 months), monitor magnesium levels.
- For prolonged use (over 1 year), monitor Vitamin B12 levels.
- Consider bone density monitoring in patients at risk for osteoporosis.
Doctor Notes
- Advise patients on lifestyle modifications to complement drug therapy.
- For long-term PPI users, consider intermittent therapy or dose reduction if appropriate.
- Monitor for potential adverse effects, especially with prolonged use, such as hypomagnesemia and bone health.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly without consulting your doctor.
- Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements.
- If symptoms do not improve or worsen, contact your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Generally, Ornova 20 mg does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid trigger foods that worsen acid reflux (e.g., spicy, fatty foods, caffeine, carbonated drinks).
- Quit smoking and reduce alcohol consumption, as these can exacerbate acid-related conditions.
- Eat smaller, more frequent meals and avoid lying down immediately after eating.
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