Oroxat
Generic Name
oroxat-70-mg-tablet
Manufacturer
MediCorp Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oroxat 70 mg tablet | ৳ 400.00 | ৳ 1,200.00 |
Description
Overview of the medicine
Oroxat 70 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
70 mg once or twice daily, or as directed by physician. Maximum daily dose is 140 mg.
Elderly
Lower doses recommended, 70 mg once daily, with careful monitoring due to increased risk of adverse effects.
Renal_impairment
Use with caution. Dose reduction may be necessary in patients with moderate to severe renal impairment.
How to Take
Take Oroxat 70 mg Tablet orally, preferably with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water.
Mechanism of Action
Oroxat 70 mg Tablet inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis.
Pharmacokinetics
Onset
Within 30-60 minutes.
Excretion
Mainly renal, with about 60-70% excreted in urine and some biliary excretion.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-2 hours.
Metabolism
Primarily hepatic, via CYP450 enzymes, forming inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Oroxat or other NSAIDs (e.g., aspirin, ibuprofen)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus
- Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Severe uncontrolled heart failure
Drug Interactions
Lithium
Increased lithium plasma levels and potential for toxicity due to reduced renal clearance.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Warfarin and other anticoagulants
Increased risk of bleeding due to additive antiplatelet effects.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, potential for renal impairment.
ACE inhibitors and Angiotensin II receptor blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Oroxat 70 mg Tablet overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, blurred vision, dizziness, and headache. More severe symptoms can include gastrointestinal bleeding, acute renal failure, and respiratory depression. Management includes symptomatic and supportive care, gastric lavage, administration of activated charcoal, and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category C. Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Oroxat 70 mg Tablet is excreted in breast milk; use with caution or consider alternatives while breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Oroxat or other NSAIDs (e.g., aspirin, ibuprofen)
- Active gastrointestinal bleeding or peptic ulcer disease
- Severe renal or hepatic impairment
- Third trimester of pregnancy due to risk of premature closure of fetal ductus arteriosus
- Perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
- Severe uncontrolled heart failure
Drug Interactions
Lithium
Increased lithium plasma levels and potential for toxicity due to reduced renal clearance.
Methotrexate
Increased methotrexate toxicity due to reduced renal clearance.
Warfarin and other anticoagulants
Increased risk of bleeding due to additive antiplatelet effects.
Diuretics (e.g., Furosemide, Thiazides)
Reduced diuretic and antihypertensive effects, potential for renal impairment.
ACE inhibitors and Angiotensin II receptor blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of Oroxat 70 mg Tablet overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, blurred vision, dizziness, and headache. More severe symptoms can include gastrointestinal bleeding, acute renal failure, and respiratory depression. Management includes symptomatic and supportive care, gastric lavage, administration of activated charcoal, and monitoring of vital signs.
Pregnancy & Lactation
Pregnancy Category C. Avoid during the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Oroxat 70 mg Tablet is excreted in breast milk; use with caution or consider alternatives while breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Patented
Clinical Trials
Clinical trial information supporting the efficacy and safety of Oroxat 70 mg Tablet is available through regulatory submissions to relevant health authorities.
Lab Monitoring
- Complete blood count (CBC) for anemia or bleeding
- Liver function tests (LFTs) for hepatic toxicity
- Renal function tests (RFTs) including serum creatinine and BUN for kidney function
- Blood pressure monitoring, especially in patients with hypertension
Doctor Notes
- Educate patients on the potential GI and cardiovascular risks associated with NSAID use.
- Monitor renal function, liver enzymes, and blood pressure periodically, especially in elderly patients or those with pre-existing conditions.
- Advise patients to report any symptoms of GI bleeding or cardiovascular events promptly.
- Consider the lowest effective dose for the shortest possible duration.
Patient Guidelines
- Take Oroxat 70 mg Tablet exactly as prescribed by your doctor.
- Do not exceed the recommended dose to avoid serious side effects.
- Report any unusual bleeding, persistent stomach upset, swelling, or dark stools to your doctor immediately.
- Avoid consuming alcohol while on this medication.
Missed Dose Advice
If you miss a dose of Oroxat 70 mg Tablet, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Oroxat 70 mg Tablet may cause dizziness or drowsiness in some individuals. Patients should be cautioned about operating machinery or driving until they know how Oroxat affects them.
Lifestyle Advice
- Maintain a healthy and balanced diet.
- Avoid smoking, as it may increase the risk of gastrointestinal bleeding.
- Limit alcohol intake, as it can exacerbate gastrointestinal side effects.
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