Ortical
Generic Name
Calcium Orotate 400 mg
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ortical 400 mg tablet | ৳ 8.03 | ৳ 80.30 |
Description
Overview of the medicine
Calcium Orotate is an advanced form of calcium supplement known for its superior bioavailability. It is used to prevent and treat calcium deficiencies and support bone health.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by physician.
Elderly
Same as adults, or as directed, possibly with renal function monitoring.
Renal_impairment
Caution advised, dose adjustment may be needed based on calcium levels and renal function.
How to Take
Oral, with or without food, preferably with a meal for better absorption or as directed by a healthcare professional.
Mechanism of Action
Calcium Orotate delivers calcium, a vital mineral, to the body's cells. The orotate ion acts as a 'carrier' to facilitate calcium's absorption and utilization by bones and other tissues, thereby supporting bone strength and various physiological functions.
Pharmacokinetics
Onset
Gradual.
Excretion
Primarily renal (urine) and fecal.
Half life
Varies; elemental calcium has a complex pharmacokinetic profile. For supplementation, sustained levels are important.
Absorption
Enhanced absorption due to orotate carrier, higher bioavailability than other calcium salts.
Metabolism
Calcium is not metabolized in the traditional sense; orotate is metabolized.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels in blood)
- Severe renal impairment
- Hypersensitivity to any component of the formulation
Drug Interactions
Bisphosphonates
May reduce absorption. Separate administration.
Thiazide diuretics
May increase risk of hypercalcemia.
Thyroid hormones (e.g., levothyroxine)
May reduce absorption of thyroid hormones. Separate administration by several hours.
Tetracyclines & Quinolones (antibiotics)
May reduce absorption. Separate administration by several hours.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypercalcemia (nausea, vomiting, constipation, confusion, muscle weakness). Management includes stopping calcium, hydration, diuretics, and potentially calcitonin or bisphosphonates.
Pregnancy & Lactation
Generally considered safe and often recommended as a supplement during pregnancy and lactation, but consult a doctor.
Side Effects
Contraindications
- Hypercalcemia (high calcium levels in blood)
- Severe renal impairment
- Hypersensitivity to any component of the formulation
Drug Interactions
Bisphosphonates
May reduce absorption. Separate administration.
Thiazide diuretics
May increase risk of hypercalcemia.
Thyroid hormones (e.g., levothyroxine)
May reduce absorption of thyroid hormones. Separate administration by several hours.
Tetracyclines & Quinolones (antibiotics)
May reduce absorption. Separate administration by several hours.
Storage
Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe hypercalcemia (nausea, vomiting, constipation, confusion, muscle weakness). Management includes stopping calcium, hydration, diuretics, and potentially calcitonin or bisphosphonates.
Pregnancy & Lactation
Generally considered safe and often recommended as a supplement during pregnancy and lactation, but consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Off-patent (generic formulation)
Clinical Trials
Ongoing research compares calcium orotate's efficacy and absorption profile with other calcium salts, particularly in specific populations or for long-term bone health outcomes.
Lab Monitoring
- Serum calcium levels (especially with long-term high dose use or in renal impairment)
- Renal function tests
Doctor Notes
- Advise patients on adequate fluid intake to minimize potential for constipation and kidney stone formation.
- Monitor serum calcium levels periodically, especially in patients with renal impairment or those on concomitant medications that affect calcium metabolism.
Patient Guidelines
- Do not exceed recommended dose.
- Inform doctor about all other medications and supplements you are taking.
- Maintain adequate fluid intake.
- Report any severe side effects to your doctor.
Missed Dose Advice
Take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and resume your regular schedule. Do not double the dose.
Driving Precautions
Not expected to affect driving ability.
Lifestyle Advice
- Maintain a balanced diet rich in calcium and Vitamin D.
- Engage in regular weight-bearing exercise.
- Limit excessive caffeine, alcohol, and sodium intake.
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