Ortical
Generic Name
Ortical-740-mg-tablet
Manufacturer
Medix Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ortical 740 mg tablet | ৳ 10.00 | ৳ 100.00 |
Description
Overview of the medicine
Ortical 740 mg Tablet is a mineral supplement primarily used to prevent and treat calcium deficiencies. It plays a vital role in maintaining bone health, muscle function, nerve transmission, and various metabolic processes. It is often prescribed for conditions like osteoporosis, osteomalacia, and in situations of increased calcium demand such as pregnancy and lactation.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by the physician. It can be taken with or without food.
Elderly
Same as adult dosage, with careful monitoring of calcium levels due to potential renal impairment.
Renal_impairment
Use with caution; dosage adjustment may be required. Regular monitoring of serum calcium and phosphate levels is necessary.
How to Take
Take the tablet orally, with a glass of water. It can be taken with or without food. For better absorption, it is sometimes recommended to take it with meals.
Mechanism of Action
As a calcium supplement, Ortical 740 mg provides elemental calcium, which is essential for maintaining proper calcium levels in the body. Calcium is involved in bone mineralization, muscle contraction, blood coagulation, nerve signal transmission, and hormone secretion. By increasing the available calcium, it helps to normalize physiological functions and strengthen bones.
Pharmacokinetics
Onset
Effects on systemic calcium levels are generally observed within hours, but skeletal benefits require chronic administration.
Excretion
Excess calcium is primarily excreted via the kidneys in urine, with some excretion through feces.
Half life
The half-life of calcium in blood is complex due to its constant turnover in bone and soft tissues, but its physiological effects are sustained with regular dosing.
Absorption
Calcium absorption primarily occurs in the small intestine, mainly through active transport and passive diffusion. Bioavailability can vary depending on the salt form and presence of vitamin D.
Metabolism
Elemental calcium is not metabolized in the traditional sense; it is an essential ion used throughout the body.
Side Effects
Contraindications
- Hypersensitivity to calcium salts or any component of the tablet.
- Hypercalcemia (abnormally high levels of calcium in the blood).
- Severe hypercalciuria (excessive calcium in urine).
- Nephrolithiasis (kidney stones) or history of kidney stones.
- Severe renal impairment.
Drug Interactions
Digoxin
High calcium levels can increase the risk of digoxin toxicity.
Tetracyclines (e.g., Doxycycline)
Calcium can chelate tetracyclines, reducing their absorption. Administer calcium at least 2-3 hours before or after tetracycline.
Bisphosphonates (e.g., Alendronate)
Calcium can interfere with bisphosphonate absorption. Take calcium at least 30 minutes after bisphosphonates.
Fluoroquinolones (e.g., Ciprofloxacin)
Similar to tetracyclines, calcium can impair fluoroquinolone absorption. Separate administration times.
Thyroid hormones (e.g., Levothyroxine)
Calcium may reduce absorption of thyroid hormones. Administer at least 4 hours apart.
Thiazide diuretics (e.g., Hydrochlorothiazide)
Can reduce renal excretion of calcium, increasing risk of hypercalcemia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria, polydipsia, confusion, and in severe cases, cardiac arrhythmias and coma. Management involves immediate discontinuation of the supplement, rehydration, and in severe cases, loop diuretics or bisphosphonates under medical supervision.
Pregnancy & Lactation
Calcium is essential during pregnancy and lactation. Ortical 740 mg Tablet can be used safely under medical supervision to meet increased calcium requirements. However, doses should not exceed the recommended daily allowance to avoid hypercalcemia in the mother or fetus/infant.
Side Effects
Contraindications
- Hypersensitivity to calcium salts or any component of the tablet.
- Hypercalcemia (abnormally high levels of calcium in the blood).
- Severe hypercalciuria (excessive calcium in urine).
- Nephrolithiasis (kidney stones) or history of kidney stones.
- Severe renal impairment.
Drug Interactions
Digoxin
High calcium levels can increase the risk of digoxin toxicity.
Tetracyclines (e.g., Doxycycline)
Calcium can chelate tetracyclines, reducing their absorption. Administer calcium at least 2-3 hours before or after tetracycline.
Bisphosphonates (e.g., Alendronate)
Calcium can interfere with bisphosphonate absorption. Take calcium at least 30 minutes after bisphosphonates.
Fluoroquinolones (e.g., Ciprofloxacin)
Similar to tetracyclines, calcium can impair fluoroquinolone absorption. Separate administration times.
Thyroid hormones (e.g., Levothyroxine)
Calcium may reduce absorption of thyroid hormones. Administer at least 4 hours apart.
Thiazide diuretics (e.g., Hydrochlorothiazide)
Can reduce renal excretion of calcium, increasing risk of hypercalcemia.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, abdominal pain, muscle weakness, polyuria, polydipsia, confusion, and in severe cases, cardiac arrhythmias and coma. Management involves immediate discontinuation of the supplement, rehydration, and in severe cases, loop diuretics or bisphosphonates under medical supervision.
Pregnancy & Lactation
Calcium is essential during pregnancy and lactation. Ortical 740 mg Tablet can be used safely under medical supervision to meet increased calcium requirements. However, doses should not exceed the recommended daily allowance to avoid hypercalcemia in the mother or fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Available in pharmacies and superstores nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic
Clinical Trials
Clinical trials have established the efficacy and safety of calcium supplementation in preventing and treating bone-related conditions and deficiencies.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or those on high doses).
- Renal function (creatinine clearance).
- Serum phosphate levels.
Doctor Notes
- Advise patients to maintain adequate fluid intake to minimize the risk of kidney stones.
- Consider assessing Vitamin D levels, as optimal Vitamin D is crucial for calcium absorption.
- Caution in patients with a history of hypercalcemia or renal calculii.
Patient Guidelines
- Take the tablet with sufficient water.
- Do not exceed the recommended dose without consulting a doctor.
- Inform your doctor about all other medications you are taking.
- Maintain a balanced diet rich in calcium and Vitamin D.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ortical 740 mg Tablet is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Ensure adequate intake of Vitamin D through diet or sunlight exposure, as it aids calcium absorption.
- Engage in regular weight-bearing exercises to promote bone health.
- Limit consumption of alcohol and caffeine, which can negatively impact calcium balance.
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