Administered by slow intravenous infusion through a peripheral or central venous catheter. Must be filtered prior to administration using a filter to ensure removal of any crystals.

Osmosol increases the osmotic pressure of the glomerular filtrate, inhibiting tubular reabsorption of water and electrolytes, leading to increased excretion of water, sodium, and chloride. It also draws water from extravascular compartments, such as the brain and eye, into the vascular system, reducing edema and pressure.

• •Known hypersensitivity to Osmosol
• •Severe dehydration
• •Anuria
• •Active intracranial bleeding (except during craniotomy)
• •Severe pulmonary congestion or frank pulmonary edema
• •Severe heart failure

Store at controlled room temperature (20-25°C). Do not freeze. Protect from light. Crystallization may occur at low temperatures; warm to dissolve.

Symptoms include severe fluid and electrolyte disturbances (e.g., hypernatremia, hyponatremia, hyperkalemia, hypokalemia), acute renal failure, increased intracranial pressure (rebound effect), and heart failure due to fluid overload. Treatment involves discontinuing Osmosol, correcting electrolyte imbalances, and supportive care.

Pregnancy category C. Use only if potential benefit justifies the potential risk to the fetus. Caution advised during lactation; consult physician.