Ostogen D Forte
Generic Name
Calcium Carbonate + Vitamin D3 (Cholecalciferol)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ostogen d forte 600 mg tablet | ৳ 7.00 | N/A |
Description
Overview of the medicine
Ostogen D Forte is a dietary supplement containing Calcium Carbonate and Vitamin D3, essential for maintaining strong bones, teeth, and overall skeletal health. It helps prevent and treat calcium and vitamin D deficiencies, and is used in conditions like osteoporosis.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by a physician. Should be taken with meals.
Elderly
Same as adults, but may require more careful monitoring of calcium levels, especially with co-morbidities or other medications.
Renal_impairment
Use with caution. Dosage adjustment may be necessary in severe renal impairment. Monitor serum calcium and phosphate levels regularly.
How to Take
Oral. Tablets should be swallowed whole, preferably with meals to enhance absorption and reduce gastrointestinal discomfort. Do not chew or crush.
Mechanism of Action
Calcium carbonate provides elemental calcium, a vital mineral for bone formation and maintenance. Vitamin D3 (Cholecalciferol) facilitates the absorption of calcium from the gastrointestinal tract and its incorporation into bone structure, playing a crucial role in calcium homeostasis.
Pharmacokinetics
Onset
Gradual, benefits seen over weeks to months with consistent use for bone health.
Excretion
Calcium is mainly excreted via feces (unabsorbed) and urine. Vitamin D metabolites are primarily excreted via bile and feces, with small amounts via urine.
Half life
Calcium has complex pharmacokinetics, approximately 20% excreted daily. Vitamin D3 has a half-life of 15-30 days for its active form.
Absorption
Calcium absorption varies but is enhanced by Vitamin D. Vitamin D3 is absorbed in the small intestine, primarily from fatty foods.
Metabolism
Calcium is not metabolized in the traditional sense. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3, then in the kidney to 1,25-dihydroxyvitamin D3 (calcitriol, the active form).
Side Effects
Contraindications
- Hypersensitivity to any component
- Hypercalcemia (high calcium levels in blood)
- Hypercalciuria (high calcium levels in urine)
- Severe renal impairment
- Kidney stones (nephrolithiasis) or history of kidney stones
- Hypervitaminosis D
Drug Interactions
Bisphosphonates
Calcium can reduce absorption. Take at least 30-60 minutes before calcium supplements.
Corticosteroids
Can decrease calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing urinary calcium excretion.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia from vitamin D can increase the risk of cardiac arrhythmias. Monitor calcium levels closely.
Tetracycline and Quinolone antibiotics
Calcium can reduce absorption of these antibiotics. Take at least 2 hours before or 4-6 hours after calcium supplements.
Thyroid hormones (e.g., Levothyroxine)
Calcium can reduce absorption. Take at least 4 hours apart.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, thirst, polyuria (frequent urination), muscle weakness, fatigue, anorexia, and in severe cases, cardiac arrhythmias and kidney damage. Treatment involves discontinuation of the supplement, rehydration, and medical management to lower calcium levels.
Pregnancy & Lactation
Generally considered safe and essential during pregnancy and lactation, but use under medical supervision to ensure appropriate dosing. Adequate calcium and vitamin D are crucial for fetal bone development and maternal health, but excessive intake should be avoided.
Side Effects
Contraindications
- Hypersensitivity to any component
- Hypercalcemia (high calcium levels in blood)
- Hypercalciuria (high calcium levels in urine)
- Severe renal impairment
- Kidney stones (nephrolithiasis) or history of kidney stones
- Hypervitaminosis D
Drug Interactions
Bisphosphonates
Calcium can reduce absorption. Take at least 30-60 minutes before calcium supplements.
Corticosteroids
Can decrease calcium absorption.
Thiazide diuretics
May increase the risk of hypercalcemia by reducing urinary calcium excretion.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia from vitamin D can increase the risk of cardiac arrhythmias. Monitor calcium levels closely.
Tetracycline and Quinolone antibiotics
Calcium can reduce absorption of these antibiotics. Take at least 2 hours before or 4-6 hours after calcium supplements.
Thyroid hormones (e.g., Levothyroxine)
Calcium can reduce absorption. Take at least 4 hours apart.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children. Do not freeze.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, thirst, polyuria (frequent urination), muscle weakness, fatigue, anorexia, and in severe cases, cardiac arrhythmias and kidney damage. Treatment involves discontinuation of the supplement, rehydration, and medical management to lower calcium levels.
Pregnancy & Lactation
Generally considered safe and essential during pregnancy and lactation, but use under medical supervision to ensure appropriate dosing. Adequate calcium and vitamin D are crucial for fetal bone development and maternal health, but excessive intake should be avoided.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the manufacturing date, consult product packaging for exact details.
Availability
Pharmacies, drugstores
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic (Patent expired)
Clinical Trials
Calcium and Vitamin D are extensively studied components. Ongoing clinical trials often focus on specific populations, optimal dosing, and long-term outcomes in bone health and other conditions.
Lab Monitoring
- Serum calcium levels (especially in long-term therapy or renal impairment)
- Serum phosphate levels
- 25-hydroxyvitamin D levels (if deficiency is suspected or being treated)
- Renal function (creatinine, GFR) in patients with kidney problems
Doctor Notes
- Emphasize the importance of adequate dietary calcium and vitamin D alongside supplementation.
- Regularly monitor serum calcium levels in patients on long-term therapy or with pre-existing renal impairment.
- Advise patients about potential drug interactions, especially with antibiotics, bisphosphonates, and thyroid hormones.
Patient Guidelines
- Take Ostogen D Forte exactly as prescribed by your doctor or as indicated on the package.
- Do not exceed the recommended dose without consulting your doctor.
- Take the tablet with food to maximize absorption and minimize gastrointestinal side effects.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any unusual symptoms or persistent side effects to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ostogen D Forte is not known to affect the ability to drive or operate machinery. However, if you experience any side effects that impair your concentration or reaction time, avoid such activities.
Lifestyle Advice
- Maintain a balanced diet rich in calcium (dairy products, leafy greens) and vitamin D (fatty fish).
- Engage in regular weight-bearing exercises to promote bone strength.
- Ensure adequate sun exposure (10-15 minutes, 2-3 times a week) for natural Vitamin D synthesis, if possible and safe.
- Avoid excessive alcohol consumption and smoking, as they can negatively affect bone health.
- Stay well-hydrated.
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