Oxiquin
Generic Name
oxiquin-400-mg-tablet
Manufacturer
Acme Pharmaceuticals
Country
United States
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxiquin 400 mg tablet | ৳ 23.00 | ৳ 230.00 |
Description
Overview of the medicine
Oxiquin 400 mg Tablet, containing Ofloxacin as its active ingredient, is a broad-spectrum fluoroquinolone antibiotic used to treat a wide range of bacterial infections in various parts of the body.
Uses & Indications
Dosage
Adults
Typical adult dosage is 400 mg once daily or 200 mg twice daily, depending on the severity and type of infection. Treatment duration varies based on the infection.
Elderly
No specific dose adjustment is required based solely on age, but renal function should be assessed, and dose adjusted if impairment is present.
Renal_impairment
Dose adjustment is necessary for patients with impaired renal function. Consult product literature for specific creatinine clearance guidelines.
How to Take
Take orally with or without food. Do not take with antacids containing magnesium or aluminum, iron or zinc supplements, or sucralfate within 2 hours of taking Ofloxacin, as they can reduce absorption.
Mechanism of Action
Ofloxacin, the active ingredient in Oxiquin, inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.
Pharmacokinetics
Onset
Onset of action is relatively rapid, with clinical effects typically observed within hours to days depending on the infection.
Excretion
Primarily excreted unchanged in the urine (80-90% within 24-48 hours). Renal impairment necessitates dose adjustment.
Half life
The elimination half-life is typically 4-6 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 90-100%. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver, with less than 10% of the dose being metabolized.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin, other quinolones, or any excipients.
- History of tendinitis or tendon rupture associated with quinolone use.
- Patients with epilepsy or other seizure disorders.
- Children and adolescents (due to risk of cartilage damage).
- Pregnancy and lactation (generally not recommended).
Drug Interactions
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Theophylline
Ofloxacin may increase serum concentrations of theophylline, leading to increased risk of theophylline toxicity. Monitor theophylline levels.
Corticosteroids
Increased risk of tendon rupture when co-administered with corticosteroids, especially in elderly patients.
Antacids, Iron/Zinc supplements, Sucralfate
May significantly reduce the absorption of Ofloxacin. Administer Ofloxacin at least 2 hours before or 2 hours after these agents.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of CNS stimulation and convulsive seizures.
Antidiabetic agents (e.g., insulin, sulfonylureas)
May cause dysglycemia (hypoglycemia or hyperglycemia). Monitor blood glucose levels closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, dizziness, confusion, disorientation, seizures, and prolonged QT interval. Management typically involves gastric lavage, administration of activated charcoal, maintaining adequate hydration, and supportive symptomatic care. Hemodialysis or peritoneal dialysis is not significantly effective.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and may cause adverse effects in the nursing infant (e.g., cartilage damage); therefore, it is generally not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Ofloxacin, other quinolones, or any excipients.
- History of tendinitis or tendon rupture associated with quinolone use.
- Patients with epilepsy or other seizure disorders.
- Children and adolescents (due to risk of cartilage damage).
- Pregnancy and lactation (generally not recommended).
Drug Interactions
Warfarin
May potentiate the anticoagulant effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.
Theophylline
Ofloxacin may increase serum concentrations of theophylline, leading to increased risk of theophylline toxicity. Monitor theophylline levels.
Corticosteroids
Increased risk of tendon rupture when co-administered with corticosteroids, especially in elderly patients.
Antacids, Iron/Zinc supplements, Sucralfate
May significantly reduce the absorption of Ofloxacin. Administer Ofloxacin at least 2 hours before or 2 hours after these agents.
NSAIDs (Nonsteroidal Anti-inflammatory Drugs)
Concurrent use may increase the risk of CNS stimulation and convulsive seizures.
Antidiabetic agents (e.g., insulin, sulfonylureas)
May cause dysglycemia (hypoglycemia or hyperglycemia). Monitor blood glucose levels closely.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, dizziness, confusion, disorientation, seizures, and prolonged QT interval. Management typically involves gastric lavage, administration of activated charcoal, maintaining adequate hydration, and supportive symptomatic care. Hemodialysis or peritoneal dialysis is not significantly effective.
Pregnancy & Lactation
Pregnancy Category C. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk and may cause adverse effects in the nursing infant (e.g., cartilage damage); therefore, it is generally not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved (for Ofloxacin)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of Ofloxacin for its approved indications. Post-marketing surveillance continues to monitor for rare adverse events.
Lab Monitoring
- Renal function (creatinine clearance) in patients with kidney impairment.
- Blood glucose levels in diabetic patients, especially when co-administered with antidiabetic agents.
- INR in patients concurrently taking warfarin.
- Liver function tests in case of suspected hepatotoxicity (rare).
Doctor Notes
- Prioritize alternative antibiotics for uncomplicated infections where possible, reserving fluoroquinolones for more severe or resistant cases due to serious adverse effects.
- Counsel patients thoroughly on black box warnings, particularly tendon rupture, peripheral neuropathy, and CNS effects.
- Monitor for dysglycemia in diabetic patients and adjust antidiabetic therapy if needed.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent resistance and recurrence.
- Stay well-hydrated during treatment.
- Avoid excessive exposure to sunlight or artificial UV light, and use sunscreen if exposure is unavoidable.
- Report any new or worsening symptoms, especially tendon pain, numbness, tingling, or unusual muscle weakness, to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Oxiquin may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautioned about operating hazardous machinery or driving automobiles until they are reasonably certain that Ofloxacin therapy does not affect them adversely.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Ensure a balanced diet and adequate rest for recovery.
- Limit caffeine intake as Ofloxacin may increase caffeine's effects.
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