Oxyfer
Generic Name
Ferric Carboxymaltose
Manufacturer
Vifor Pharma (Innovator), various generics
Country
Switzerland (Innovator)
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxyfer 500 mg injection | ৳ 700.00 | N/A |
Description
Overview of the medicine
Ferric Carboxymaltose is an intravenous iron preparation used for treating iron deficiency anemia in adult patients who cannot tolerate oral iron or in whom oral iron is ineffective.
Uses & Indications
Dosage
Adults
Usually 15 mg/kg body weight (up to a maximum of 1000 mg) as a single dose, repeated if necessary, but with at least 7 days between doses. Total cumulative dose should not exceed 1000 mg per week.
Elderly
No specific dose adjustments are required for elderly patients, but caution is advised due to potential comorbidities.
Renal_impairment
No dose adjustment needed for patients with non-dialysis dependent chronic kidney disease. Use with caution in patients on hemodialysis.
How to Take
Administered intravenously as a slow injection or infusion. Must be diluted in 0.9% sodium chloride solution before infusion. Administer slowly over a period of 15 minutes to 30 minutes, depending on the dose.
Mechanism of Action
Ferric Carboxymaltose is a colloidal iron hydroxide complex with a carbohydrate ligand that releases iron slowly into the reticuloendothelial system, where it is incorporated into ferritin and subsequently into hemoglobin.
Pharmacokinetics
Onset
Increase in hemoglobin levels typically seen within weeks.
Excretion
Iron is primarily stored in the reticuloendothelial system; only minimal amounts are excreted, mainly in feces and urine.
Half life
Circulating half-life for total iron is approximately 7-12 hours.
Absorption
Administered intravenously, hence bioavailability is 100%. Iron is released from the complex primarily in the reticuloendothelial system.
Metabolism
Iron is separated from the carbohydrate shell and either incorporated into iron stores (ferritin) or transported via transferrin for erythropoiesis.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any of its excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia, megaloblastic anemia).
- Iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
Oral Iron Preparations
Concurrent administration of oral iron preparations may reduce the absorption of oral iron. Oral iron should be started only after at least 5 days following the last injection of ferric carboxymaltose.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose may lead to iron overload (hemosiderosis). Treatment includes supportive measures and chelation therapy if severe.
Pregnancy & Lactation
Not recommended in the first trimester of pregnancy. Use in second and third trimesters only if clearly needed and potential benefit outweighs risk. Small amounts of iron are excreted in breast milk; caution is advised when administering to a nursing woman.
Side Effects
Contraindications
- Hypersensitivity to Ferric Carboxymaltose or any of its excipients.
- Anemia not caused by iron deficiency (e.g., hemolytic anemia, megaloblastic anemia).
- Iron overload or disturbances in iron utilization.
- First trimester of pregnancy.
Drug Interactions
Oral Iron Preparations
Concurrent administration of oral iron preparations may reduce the absorption of oral iron. Oral iron should be started only after at least 5 days following the last injection of ferric carboxymaltose.
Storage
Store below 30°C. Do not freeze. Protect from light. Keep out of reach of children.
Overdose
Overdose may lead to iron overload (hemosiderosis). Treatment includes supportive measures and chelation therapy if severe.
Pregnancy & Lactation
Not recommended in the first trimester of pregnancy. Use in second and third trimesters only if clearly needed and potential benefit outweighs risk. Small amounts of iron are excreted in breast milk; caution is advised when administering to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, check product label for exact expiry date.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Patent expired for original molecule, generic versions available globally.
Clinical Trials
Extensive clinical trials (e.g., FIND-CKD, FERGILE) have demonstrated efficacy and safety in various patient populations with iron deficiency anemia.
Lab Monitoring
- Hemoglobin (Hb)
- Serum ferritin
- Transferrin saturation (TSAT)
- Full blood count (FBC)
Doctor Notes
- Pre-screen patients for iron deficiency prior to administration.
- Closely monitor patients for hypersensitivity reactions during and for at least 30 minutes after infusion.
- Do not administer more than 1000 mg (20 mg/kg) per week. Consider iron status re-evaluation after 4 weeks.
Patient Guidelines
- Report any symptoms of allergic reactions immediately during or after infusion.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and supplements.
- Do not take oral iron supplements unless advised by your doctor.
Missed Dose Advice
As this is an intravenous medication administered by a healthcare professional, a missed dose is unlikely. If a scheduled dose is missed, contact your doctor to reschedule.
Driving Precautions
Dizziness or lightheadedness may occur. Avoid driving or operating machinery if you experience these symptoms.
Lifestyle Advice
- Maintain a balanced diet (though oral iron is not for treatment here). Follow up with your doctor for regular monitoring of your iron levels and overall health.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Oxyfer Brand
Other medicines available under the same brand name
