Oxyfer
Generic Name
Iron Sucrose
Manufacturer
Reputable Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| oxyfer 750 mg injection | ৳ 1,000.00 | N/A |
Description
Overview of the medicine
Iron sucrose is an intravenous iron preparation used for the treatment of iron deficiency anemia in various patient populations, particularly those with chronic kidney disease (CKD) who cannot tolerate or respond to oral iron. It replenishes iron stores and supports hemoglobin synthesis.
Uses & Indications
Dosage
Adults
The total cumulative dose of Oxyfer for treatment is individualized and based on the patient’s total iron deficit. A common cumulative dose can be 1000 mg, often given as 200 mg (5mL) diluted in 100 mL normal saline, administered slowly over 2-5 separate sessions. For 750 mg, it could be 3 doses of 250 mg or 1 dose of 500 mg followed by 1 dose of 250 mg.
Elderly
No specific dosage adjustment is required for elderly patients beyond adult doses, but close monitoring for adverse effects is recommended due to potential comorbidities.
Renal_impairment
No specific dosage adjustment is needed, as chronic kidney disease is a primary indication. However, iron status should be monitored closely to prevent iron overload.
How to Take
Oxyfer 750 mg Injection should be administered intravenously by slow infusion or slow injection by a healthcare professional. It should be diluted in 0.9% sodium chloride solution prior to infusion. Never administer as a rapid IV bolus due to the risk of hypotensive reactions. Observe patients for signs of hypersensitivity during and after administration.
Mechanism of Action
Iron sucrose dissociates into iron and sucrose. The iron component is then transported to the body's iron stores (e.g., bone marrow, liver, spleen) where it is incorporated into hemoglobin, myoglobin, and iron-containing enzymes. Sucrose is metabolized.
Pharmacokinetics
Onset
Iron becomes available within minutes to hours; therapeutic effects (e.g., hemoglobin rise) are observed over weeks.
Excretion
Mainly via the reticuloendothelial system. Minimal renal excretion of intact iron sucrose.
Half life
Approximately 6 hours for total iron in serum.
Absorption
Administered intravenously, hence 100% bioavailable.
Metabolism
Iron is separated from the sucrose complex and primarily incorporated into transferrin, ferritin, and hemosiderin. Sucrose is metabolized.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components.
- Anemias not caused by iron deficiency (e.g., hemolytic anemia, vitamin B12 deficiency).
- Iron overload (e.g., hemochromatosis, hemosiderosis) or disturbances in iron utilization.
- First trimester of pregnancy (due to potential risks of anaphylaxis).
Drug Interactions
ACE Inhibitors
Some studies suggest a potential increased risk of hypersensitivity reactions when iron sucrose is administered concurrently with ACE inhibitors, though this is not consistently proven.
Oral Iron Preparations
Intravenous iron preparations may reduce the absorption of oral iron. Oral iron administration should be started at least 5 days after the last iron sucrose injection.
Storage
Store at room temperature (20-25°C). Do not freeze. Protect from light. Do not mix with other medications or use if particulate matter is present.
Overdose
Overdose of iron sucrose can lead to iron overload (hemochromatosis), which can be severe and life-threatening. Symptoms may include hypotension, collapse, nausea, vomiting, and abdominal pain. Management involves discontinuing the drug, supportive care, and, if severe, iron chelation therapy (e.g., deferoxamine).
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use with caution during the second and third trimesters if clearly needed. Avoid during the first trimester. Use with caution in breastfeeding mothers; benefits should outweigh potential risks.
Side Effects
Contraindications
- Known hypersensitivity to iron sucrose or any of its components.
- Anemias not caused by iron deficiency (e.g., hemolytic anemia, vitamin B12 deficiency).
- Iron overload (e.g., hemochromatosis, hemosiderosis) or disturbances in iron utilization.
- First trimester of pregnancy (due to potential risks of anaphylaxis).
Drug Interactions
ACE Inhibitors
Some studies suggest a potential increased risk of hypersensitivity reactions when iron sucrose is administered concurrently with ACE inhibitors, though this is not consistently proven.
Oral Iron Preparations
Intravenous iron preparations may reduce the absorption of oral iron. Oral iron administration should be started at least 5 days after the last iron sucrose injection.
Storage
Store at room temperature (20-25°C). Do not freeze. Protect from light. Do not mix with other medications or use if particulate matter is present.
Overdose
Overdose of iron sucrose can lead to iron overload (hemochromatosis), which can be severe and life-threatening. Symptoms may include hypotension, collapse, nausea, vomiting, and abdominal pain. Management involves discontinuing the drug, supportive care, and, if severe, iron chelation therapy (e.g., deferoxamine).
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use with caution during the second and third trimesters if clearly needed. Avoid during the first trimester. Use with caution in breastfeeding mothers; benefits should outweigh potential risks.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years when stored unopened in the original packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Iron sucrose has undergone extensive clinical trials demonstrating its efficacy and safety in treating iron deficiency anemia, particularly in patients with chronic kidney disease. Studies have evaluated its role in hemodialysis-dependent and non-dialysis-dependent CKD patients, as well as in other populations.
Lab Monitoring
- Hemoglobin (Hb) and Hematocrit (Hct) to assess response to therapy.
- Serum Ferritin to monitor iron stores.
- Transferrin Saturation (TSAT) to assess iron availability.
- Liver function tests (LFTs) periodically, especially with prolonged use, to monitor for iron overload.
Doctor Notes
- Pre-medication is generally not required, but have resuscitation equipment readily available.
- Administer slowly to minimize the risk of hypotension and other infusion-related reactions.
- Monitor vital signs and observe for hypersensitivity reactions during and for at least 30 minutes after infusion.
- Periodically reassess iron status (Hb, Ferritin, TSAT) to guide further treatment and prevent overload.
Patient Guidelines
- Inform your doctor about all your medical conditions, especially allergies or a history of asthma.
- Report any unusual or severe side effects immediately to your healthcare provider.
- Ensure you understand the full course of treatment and follow up with your doctor for monitoring.
- Do not take oral iron supplements unless advised by your doctor.
Missed Dose Advice
If a dose of Oxyfer Injection is missed, contact your doctor or nurse immediately to reschedule. Do not attempt to take a double dose to compensate for the missed one.
Driving Precautions
Oxyfer Injection may cause dizziness or lightheadedness in some patients. If you experience these symptoms, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain a balanced diet rich in iron, though this injection is primarily for severe deficiencies not manageable by diet alone. Regular exercise can improve overall well-being.
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