Ozil
Generic Name
Olanzapine
Manufacturer
Example Pharmaceutical Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ozil 10 mg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Olanzapine is an atypical antipsychotic medication used to treat symptoms of schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances (neurotransmitters) in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 10 mg once daily. Dosage range 5-20 mg/day based on clinical response. Bipolar mania: Initially 10-15 mg once daily. Adjust dosage as clinically indicated.
Elderly
A lower starting dose of 5 mg/day may be considered for patients 65 years or older, especially if other risk factors are present.
Renal_impairment
No routine dosage adjustment is required for mild to moderate renal impairment, but caution is advised in severe cases.
How to Take
Administer orally, once daily, with or without food. Tablets can be swallowed whole with water.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptors including dopamine D1, D2, D3, D4, serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, muscarinic M1-M5, and alpha-1 adrenergic receptors. This broad receptor binding profile contributes to its therapeutic effects in managing psychotic and mood symptoms.
Pharmacokinetics
Onset
Initial therapeutic effects may be observed within a few days, but full antipsychotic effects may take several weeks.
Excretion
Primarily urine (57%) and feces (30%).
Half life
Mean half-life is 21-54 hours (average 33 hours), allowing for once-daily dosing.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached in 5-8 hours. Food does not affect the rate or extent of absorption.
Metabolism
Primarily hepatic, via direct glucuronidation and cytochrome P450-mediated oxidation (CYP1A2 and CYP2D6).
Side Effects
Contraindications
- Known hypersensitivity to Olanzapine or any component of the formulation.
- Patients with known narrow-angle glaucoma.
Drug Interactions
Fluvoxamine
Concurrent use may increase olanzapine levels due to CYP1A2 inhibition.
Carbamazepine
May decrease olanzapine levels due to CYP1A2 induction.
Alcohol/CNS Depressants
Additive sedative effects; avoid concurrent use or use with caution.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, agitation, dysarthria, sedation, coma, and extrapyramidal symptoms. Management is supportive, including airway management, activated charcoal, and monitoring of cardiovascular function and vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Not recommended, as olanzapine is excreted in human milk and may cause adverse effects in a nursing infant.
Side Effects
Contraindications
- Known hypersensitivity to Olanzapine or any component of the formulation.
- Patients with known narrow-angle glaucoma.
Drug Interactions
Fluvoxamine
Concurrent use may increase olanzapine levels due to CYP1A2 inhibition.
Carbamazepine
May decrease olanzapine levels due to CYP1A2 induction.
Alcohol/CNS Depressants
Additive sedative effects; avoid concurrent use or use with caution.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tachycardia, agitation, dysarthria, sedation, coma, and extrapyramidal symptoms. Management is supportive, including airway management, activated charcoal, and monitoring of cardiovascular function and vital signs. There is no specific antidote.
Pregnancy & Lactation
Pregnancy: Use only if the potential benefit justifies the potential risk to the fetus. Lactation: Not recommended, as olanzapine is excreted in human milk and may cause adverse effects in a nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, depending on the manufacturer.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Olanzapine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of schizophrenia and bipolar disorder. These trials have shown significant improvements in symptom scores and relapse prevention compared to placebo or other antipsychotics. Ongoing post-marketing surveillance continues to monitor its long-term effects.
Lab Monitoring
- Blood glucose levels (fasting)
- Lipid profile (fasting)
- Weight and BMI
- Blood pressure
- Prolactin levels (if clinically indicated)
Doctor Notes
- Prioritize patient education on adherence to medication and potential metabolic side effects.
- Regularly monitor metabolic parameters (weight, glucose, lipids, blood pressure) in all patients.
- Consider lifestyle interventions (diet, exercise) to mitigate metabolic risks.
- Assess for tardive dyskinesia periodically, especially with long-term use.
- Adjust dosage cautiously in elderly or renally impaired patients.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine abruptly, even if you feel better.
- Report any unusual muscle movements, such as involuntary twitching, to your doctor immediately.
- Be aware of potential weight gain and metabolic changes; discuss with your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ozil-10 mg tablet may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Adopt a healthy diet and regular exercise to manage potential weight gain and metabolic risks.
- Avoid or limit alcohol consumption as it can increase sedative effects and worsen your condition.
- Quit smoking, as it can reduce the effectiveness of olanzapine.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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