Ozil
Generic Name
Olanzapine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ozil 5 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Olanzapine is an atypical antipsychotic medication used to treat schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain.
Uses & Indications
Dosage
Adults
Schizophrenia: Initially 5-10 mg once daily, titrate to target dose of 10-15 mg/day. Bipolar mania: Initially 10-15 mg once daily.
Elderly
A lower starting dose of 5 mg/day is recommended for elderly patients, with careful titration.
Renal_impairment
No routine dose adjustment is required in renal impairment, but caution is advised.
How to Take
Take orally once daily, with or without food. Tablets can be swallowed whole with water.
Mechanism of Action
Olanzapine acts as an antagonist at multiple receptors including serotonin 5-HT2A, dopamine D1, D2, D3, D4, histamine H1, alpha1-adrenergic, and muscarinic M1, M2, M3, M4, M5 receptors. This multifaceted action contributes to its antipsychotic and mood-stabilizing effects.
Pharmacokinetics
Onset
Clinical improvement may be seen within a few days, with full therapeutic effects in several weeks.
Excretion
Approximately 57% excreted in urine and 30% in feces, mainly as metabolites.
Half life
The elimination half-life is approximately 21-54 hours (average 33 hours).
Absorption
Well absorbed orally; peak plasma concentration achieved in approximately 5-8 hours.
Metabolism
Extensively metabolized in the liver, primarily via direct glucuronidation and cytochrome P450-mediated oxidation (CYP1A2 and CYP2D6).
Side Effects
Contraindications
- Hypersensitivity to Olanzapine or any component of the formulation
- Patients with known angle-closure glaucoma
Drug Interactions
Fluvoxamine
May inhibit olanzapine metabolism, potentially increasing olanzapine levels.
Carbamazepine
May increase olanzapine clearance, leading to decreased olanzapine levels.
Anticholinergic drugs
Increased risk of anticholinergic side effects.
Alcohol/CNS depressants
Concomitant use may enhance the sedative effects of olanzapine.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, tachycardia, extrapyramidal symptoms, hypotension, and respiratory depression. Management is supportive, including maintaining airway, oxygenation, and hydration.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Olanzapine is excreted into breast milk; breastfeeding is not recommended during treatment.
Side Effects
Contraindications
- Hypersensitivity to Olanzapine or any component of the formulation
- Patients with known angle-closure glaucoma
Drug Interactions
Fluvoxamine
May inhibit olanzapine metabolism, potentially increasing olanzapine levels.
Carbamazepine
May increase olanzapine clearance, leading to decreased olanzapine levels.
Anticholinergic drugs
Increased risk of anticholinergic side effects.
Alcohol/CNS depressants
Concomitant use may enhance the sedative effects of olanzapine.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include drowsiness, tachycardia, extrapyramidal symptoms, hypotension, and respiratory depression. Management is supportive, including maintaining airway, oxygenation, and hydration.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs risk. Olanzapine is excreted into breast milk; breastfeeding is not recommended during treatment.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Olanzapine has undergone numerous clinical trials demonstrating its efficacy and safety in treating schizophrenia and bipolar disorder. Ongoing research continues to explore its long-term effects and potential new indications.
Lab Monitoring
- Fasting blood glucose (due to risk of hyperglycemia)
- Lipid profile (due to risk of dyslipidemia)
- Weight and BMI (regularly)
- Liver function tests (baseline and periodically)
Doctor Notes
- Monitor patients for metabolic changes (weight, blood glucose, lipids) at baseline and periodically.
- Regularly assess for the emergence of tardive dyskinesia, particularly with long-term use.
- Educate patients on the importance of adherence and potential side effects.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking Olanzapine suddenly without consulting your doctor, as this can worsen your condition.
- Report any unusual or severe side effects to your doctor immediately.
- Avoid alcohol while on this medication.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Ozil (Olanzapine) may cause drowsiness, dizziness, or blurred vision. Avoid driving or operating heavy machinery until you know how the medication affects you.
Lifestyle Advice
- Maintain a healthy diet and regular exercise to help manage potential weight gain.
- Stay hydrated by drinking plenty of water.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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