Pacet
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Renata Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pacet 100 mg tablet | ৳ 5.03 | ৳ 50.29 |
Description
Overview of the medicine
Pacet 100 mg tablet contains Paracetamol (Acetaminophen) as its active ingredient. It is primarily used to relieve mild to moderate pain and reduce fever, especially in infants and young children.
Uses & Indications
Dosage
Adults
Not typically used for adults; higher strengths are generally recommended.
Elderly
Not typically used for elderly patients; higher strengths are generally recommended.
Renal_impairment
Dosage interval may need to be extended in severe renal impairment (e.g., every 8 hours for GFR < 10 mL/min). Consult physician.
How to Take
Oral administration. For infants and young children, the tablet can be dissolved in a small amount of water (e.g., 5-10 ml) or chewed if age-appropriate. Dosage is typically 10-15 mg/kg body weight per dose, every 4-6 hours as needed, not exceeding 60 mg/kg/day or 4 doses in 24 hours.
Mechanism of Action
Paracetamol is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis by blocking cyclooxygenase (COX) enzymes, particularly COX-2. Its antipyretic effect is due to direct action on the hypothalamic heat-regulating center, increasing peripheral vasodilation and sweating.
Pharmacokinetics
Onset
Analgesia: 30-60 minutes; Antipyresis: <60 minutes
Excretion
Mainly excreted in urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1 to 3 hours (adults), slightly shorter in children.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10 to 60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation pathways. A small amount is metabolized by cytochrome P450 into a highly reactive intermediate (NAPQI).
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or any component of the formulation
- •Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increases risk of hepatotoxicity, especially with chronic excessive use.
Warfarin
May increase anticoagulant effect (INR) with prolonged daily use, increasing bleeding risk.
Cholestyramine
May decrease the absorption of paracetamol.
Metoclopramide, Domperidone
May increase the absorption rate of paracetamol.
Carbamazepine, Phenobarbital, Phenytoin, Rifampicin
May increase the risk of hepatotoxicity due to induction of hepatic enzymes.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can cause severe, potentially fatal liver damage. Symptoms may include nausea, vomiting, abdominal pain, loss of appetite, and jaundice. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) administration.
Pregnancy & Lactation
Generally considered safe for use during pregnancy and lactation when used at recommended doses for the shortest duration necessary. Consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2 to 3 years from the manufacturing date.
Availability
Pharmacies, supermarkets
Approval Status
Approved and widely available
Patent Status
Generic; patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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