Paincare
Generic Name
Naproxen 375 mg Tablet
Manufacturer
General Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| paincare 375 mg tablet | ৳ 13.00 | ৳ 130.00 |
Description
Overview of the medicine
Paincare 375 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and fever. It is commonly prescribed for conditions like arthritis, muscle aches, menstrual pain, and acute gout.
Uses & Indications
Dosage
Adults
For rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: 375-500 mg twice daily. Maximum 1000 mg daily; for acute gout, initial dose 750 mg, then 250 mg every 8 hours until attack subsides. For mild to moderate pain, dysmenorrhea: initial 500 mg, then 250 mg every 6-8 hours as needed, not exceeding 1250 mg on the first day and 1000 mg thereafter.
Elderly
Lower doses may be required, and renal function should be monitored due to increased risk of adverse effects.
Renal_impairment
Avoid in patients with severe renal impairment (creatinine clearance < 30 mL/min). For moderate impairment, dose reduction and careful monitoring are necessary.
How to Take
Take Paincare 375 mg Tablet orally, preferably with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
Mechanism of Action
Naproxen, the active ingredient in Paincare, works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition leads to a reduction in prostaglandin synthesis, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effects typically begin within 1 hour.
Excretion
Excreted mainly in the urine (approximately 95%) as naproxen, 6-O-desmethylnaproxen, and their conjugates, with a small amount (less than 3%) excreted in feces.
Half life
Approximately 12-17 hours, allowing for twice-daily dosing.
Absorption
Rapid and complete absorption from the gastrointestinal tract, with peak plasma concentrations achieved in 2-4 hours.
Metabolism
Primarily metabolized in the liver via demethylation to 6-O-desmethylnaproxen, followed by glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal side effects, including ulcers and bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain. More severe symptoms can include gastrointestinal bleeding, acute renal failure, apnea, and metabolic acidosis. Management: Symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered within 4 hours of ingestion. Monitor vital signs and provide appropriate supportive therapy.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid Paincare in the third trimester of pregnancy due to potential for premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Naproxen is excreted in human milk; therefore, it is not recommended for use during lactation.
Side Effects
Contraindications
- Hypersensitivity to naproxen, aspirin, or other NSAIDs
- Active peptic ulcer or gastrointestinal bleeding
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Drug Interactions
Lithium
Increased lithium plasma concentrations, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Diuretics (e.g., Furosemide)
Reduced diuretic and antihypertensive effects.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Other NSAIDs or corticosteroids
Increased risk of gastrointestinal side effects, including ulcers and bleeding.
Antiplatelet agents (e.g., Aspirin, Clopidogrel)
Increased risk of bleeding.
ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)
Reduced antihypertensive effect and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include drowsiness, heartburn, nausea, vomiting, epigastric pain. More severe symptoms can include gastrointestinal bleeding, acute renal failure, apnea, and metabolic acidosis. Management: Symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered within 4 hours of ingestion. Monitor vital signs and provide appropriate supportive therapy.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester). Avoid Paincare in the third trimester of pregnancy due to potential for premature closure of the ductus arteriosus and renal dysfunction in the fetus. Use during the first and second trimesters only if the potential benefit justifies the potential risk to the fetus. Naproxen is excreted in human milk; therefore, it is not recommended for use during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date is printed on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Naproxen has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for various pain and inflammatory conditions over several decades. These trials have established its role as a widely used NSAID.
Lab Monitoring
- Complete Blood Count (CBC) for signs of anemia or bleeding
- Renal function tests (serum creatinine, BUN) periodically, especially in long-term therapy or in patients with risk factors
- Liver function tests (ALT, AST) periodically to monitor for hepatic injury
- Blood pressure monitoring
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing, especially for long-term therapy.
- Use the lowest effective dose for the shortest possible duration to achieve therapeutic goals.
- Monitor renal function, liver enzymes, and blood pressure periodically in patients on long-term Naproxen therapy.
- Caution in patients with fluid retention, hypertension, or heart failure.
Patient Guidelines
- Take with food or milk to minimize stomach upset.
- Do not exceed the prescribed dose or duration of treatment.
- Report any unusual bleeding, black/tarry stools, or severe abdominal pain immediately.
- Avoid concurrent use of other NSAIDs without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose of Paincare, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Paincare may cause dizziness, drowsiness, or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Limit or avoid alcohol consumption while taking Paincare, as it may increase the risk of stomach bleeding.
- Maintain a healthy and balanced diet.
- Stay adequately hydrated.
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