Paincare
Generic Name
Paracetamol (Acetaminophen)
Manufacturer
Example Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| paincare 500 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Paincare 500 mg tablet contains Paracetamol, which is a widely used medication for relieving pain and reducing fever. It works by blocking the production of certain chemical messengers in the brain that cause pain and fever.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg every 4-6 hours as needed, not exceeding 4000 mg (4g) in 24 hours.
Elderly
No specific dose adjustment is usually required, but caution should be exercised in those with impaired renal or hepatic function.
Renal_impairment
For creatinine clearance 10-50 mL/min, administer every 6 hours; for creatinine clearance <10 mL/min, administer every 8 hours.
How to Take
Paincare 500 mg tablet should be taken orally with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Paracetamol (acetaminophen) is believed to act primarily in the central nervous system, increasing the pain threshold by inhibiting cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in prostaglandin synthesis. It also acts on the hypothalamic heat-regulating center, producing antipyresis.
Pharmacokinetics
Onset
Within 30 to 60 minutes
Excretion
Mainly excreted in the urine as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1.5 to 3 hours
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 to 60 minutes after oral administration.
Metabolism
Primarily hepatic via conjugation with glucuronic acid and sulfate. A small portion is metabolized by cytochrome P450 into a toxic intermediate, NAPQI, which is then detoxified by glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity.
Warfarin
Increased anticoagulant effect, leading to increased risk of bleeding.
Other paracetamol-containing products
Increased risk of overdose and liver damage.
Phenobarbital, Phenytoin, Carbamazepine
Increased risk of hepatotoxicity due to enzyme induction.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and loss of appetite, which may appear 24 hours or more after ingestion. Severe overdose can lead to hepatic necrosis, renal tubular necrosis, cardiac abnormalities, and pancreatitis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended doses. However, always consult a doctor before taking any medication during these periods.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation
- Severe hepatic impairment or active liver disease
Drug Interactions
Alcohol
Increased risk of hepatotoxicity.
Warfarin
Increased anticoagulant effect, leading to increased risk of bleeding.
Other paracetamol-containing products
Increased risk of overdose and liver damage.
Phenobarbital, Phenytoin, Carbamazepine
Increased risk of hepatotoxicity due to enzyme induction.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and loss of appetite, which may appear 24 hours or more after ingestion. Severe overdose can lead to hepatic necrosis, renal tubular necrosis, cardiac abnormalities, and pancreatitis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during pregnancy and lactation at recommended doses. However, always consult a doctor before taking any medication during these periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, supermarkets
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Paracetamol has undergone extensive clinical trials globally, establishing its efficacy and safety profile for pain and fever management. Specific trials for 'Paincare' brand would relate to its bioequivalence to established paracetamol products.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of overdose or prolonged high-dose therapy.
- Renal function tests if prolonged use or pre-existing renal impairment.
Doctor Notes
- Advise patients on the maximum daily dose (4g for adults) and the importance of not co-administering with other paracetamol-containing products.
- Counsel on the risk of hepatotoxicity, especially with alcohol consumption or pre-existing liver conditions.
- Monitor liver function in patients on chronic therapy or with risk factors.
Patient Guidelines
- Do not exceed the recommended dose.
- Do not take with other paracetamol-containing products.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Paincare 500 mg tablet is not known to impair the ability to drive or operate machinery. However, if you experience any side effects that affect your concentration, avoid these activities.
Lifestyle Advice
- Maintain adequate hydration.
- Avoid excessive alcohol consumption while taking this medication.
- Rest adequately to aid recovery from illness.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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