Adults

For pediatric use: The recommended dose for children is 15 mg/kg body weight every 4-6 hours, not exceeding 4 doses in 24 hours. For example, a child weighing 8 kg would receive 5 mL (120 mg) every 4-6 hours. Maximum daily dose for children is 60 mg/kg, not to exceed 4g/day. This specific 120 mg/5 mL suspension is generally not recommended for adults as higher strengths are available.

Elderly

Not typically used in this formulation. Standard paracetamol dosage for elderly should be monitored for renal/hepatic function.

Renal_impairment

For severe renal impairment (CrCl <10 mL/min), dosage interval should be extended to 8 hours.

Onset

30-60 minutes for analgesia, 30 minutes for antipyresis.

Excretion

Excreted primarily in the urine as glucuronide and sulfate conjugates, with a small amount of unchanged drug.

Half life

1-4 hours (typically 2-3 hours) in adults, slightly shorter in children.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract.

Metabolism

Mainly metabolized in the liver by conjugation with glucuronic acid and sulfate, and via cytochrome P450 pathway to a toxic intermediate (NAPQI) which is rapidly detoxified by glutathione.

Warfarin

May increase anticoagulant effect (risk of bleeding) with prolonged regular use.

Cholestyramine

May decrease the rate of paracetamol absorption.

Metoclopramide, Domperidone

May increase the rate of paracetamol absorption.

Enzyme inducers (e.g., phenobarbital, carbamazepine, rifampicin)

Increased risk of hepatotoxicity with chronic use.