Panol Plus
Generic Name
Paracetamol + Caffeine
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panol plus 500 mg tablet | ৳ 1.90 | N/A |
Description
Overview of the medicine
Panol Plus is a combination medicine containing Paracetamol and Caffeine. It is primarily used for the relief of mild to moderate pain, fever, and symptoms associated with cold and flu, as well as tension headaches and migraine.
Uses & Indications
Dosage
Adults
1-2 tablets every 4-6 hours as needed. Do not exceed 8 tablets in 24 hours.
Elderly
Same as adults, but caution should be exercised in individuals with impaired hepatic or renal function.
Renal_impairment
Dose adjustment may be necessary. Consult a physician.
How to Take
Oral administration. Can be taken with or without food. To minimize gastric upset, take with food.
Mechanism of Action
Paracetamol acts primarily in the central nervous system to inhibit prostaglandin synthesis, resulting in analgesic and antipyretic effects. Caffeine is a central nervous system stimulant that enhances the analgesic effect of paracetamol and has vasoconstrictive properties, particularly useful in headache relief.
Pharmacokinetics
Onset
30-60 minutes for analgesic/antipyretic effect.
Excretion
Paracetamol and its metabolites are excreted primarily in the urine. Caffeine and its metabolites are also predominantly excreted in the urine.
Half life
Paracetamol: 1-4 hours; Caffeine: 3-7 hours.
Absorption
Both paracetamol and caffeine are rapidly and almost completely absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations for paracetamol are reached within 30-60 minutes, and for caffeine within 30-120 minutes.
Metabolism
Paracetamol is extensively metabolized in the liver, primarily by conjugation (glucuronidation and sulfation). Caffeine is also extensively metabolized in the liver by demethylation and oxidation.
Side Effects
Contraindications
- •Hypersensitivity to paracetamol or caffeine
- •Severe hepatic impairment
- •Severe renal impairment
- •Acute porphyria
Drug Interactions
Alcohol
Increased risk of hepatotoxicity.
Warfarin
Increased anticoagulant effect.
Cholestyramine
Reduced absorption of paracetamol.
Metoclopramide, Domperidone
Increased absorption of paracetamol.
Certain antibiotics (e.g., Ciprofloxacin, Enoxacin)
Increased caffeine levels.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, abdominal pain, sweating, drowsiness, and liver damage (paracetamol). Caffeine overdose can cause tremors, insomnia, nervousness, and tachycardia. Treatment involves gastric lavage, activated charcoal, and antidote (N-acetylcysteine for paracetamol overdose).
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Paracetamol is generally considered safe, but high doses of caffeine should be avoided during pregnancy. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from manufacturing date.
Availability
Pharmacies, drugstores, supermarkets
Approval Status
Approved by DGDA
Patent Status
Off-patent
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Global Brand Names
International brand names for this medicine
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