Panotem
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panotem 20 mg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor used to treat conditions involving excessive stomach acid, such as GERD, erosive esophagitis, and ulcers.
Uses & Indications
Dosage
Adults
For GERD/erosive esophagitis: 20 mg once daily for 4-8 weeks. Maintenance: 20 mg daily. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No dose adjustment generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dose adjustment is required for patients with renal impairment.
How to Take
Take orally, usually in the morning, before food. Swallow the tablet whole; do not crush, chew, or split it.
Mechanism of Action
Panotem (Pantoprazole) selectively blocks the H+/K+-ATPase enzyme system (proton pump) in gastric parietal cells, inhibiting the final step in gastric acid production.
Pharmacokinetics
Onset
Acid suppression starts within 2.5 hours, with maximum effect observed after repeated dosing.
Excretion
Primarily renal (approximately 80%) and biliary/fecal (approximately 20%).
Half life
Approximately 1 hour (terminal half-life).
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 77% and is not affected by food.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to significant reduction in their absorption.
Drug Interactions
Warfarin
Increased INR, monitor closely.
Clopidogrel
Reduced antiplatelet effect, use with caution.
Methotrexate
Increased methotrexate levels, especially with high dose methotrexate.
Atazanavir, Nelfinavir
Reduced absorption, avoid co-administration.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Pantoprazole is not readily removed from the circulation by hemodialysis.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the risks. Consult your doctor before use during pregnancy or lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to significant reduction in their absorption.
Drug Interactions
Warfarin
Increased INR, monitor closely.
Clopidogrel
Reduced antiplatelet effect, use with caution.
Methotrexate
Increased methotrexate levels, especially with high dose methotrexate.
Atazanavir, Nelfinavir
Reduced absorption, avoid co-administration.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Pantoprazole is not readily removed from the circulation by hemodialysis.
Pregnancy & Lactation
Use only if clearly needed and the potential benefits outweigh the risks. Consult your doctor before use during pregnancy or lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from the manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of pantoprazole for various acid-related disorders, demonstrating superior or comparable effects to other PPIs.
Lab Monitoring
- Magnesium levels (for long-term use, especially with diuretics)
- Liver function tests (in patients with hepatic impairment)
- Vitamin B12 levels (for prolonged use, >3 years)
Doctor Notes
- Consider the lowest effective dose for the shortest duration necessary for the condition being treated.
- Evaluate the need for continued therapy periodically, especially for long-term use.
- Be aware of potential drug interactions, particularly with warfarin, methotrexate, and clopidogrel.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop medication suddenly without consulting your doctor.
- Report any persistent or severe side effects immediately.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a forgotten one.
Driving Precautions
Panotem may cause dizziness or visual disturbances in some patients. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating and elevate your head during sleep if you have GERD.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Panotem Brand
Other medicines available under the same brand name
