Panotem
Generic Name
Pantoprazole
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panotem 40 mg tablet | ৳ 6.50 | ৳ 65.00 |
Description
Overview of the medicine
Panotem 40 mg Tablet contains Pantoprazole, a proton pump inhibitor used to reduce the amount of acid produced in the stomach. It treats conditions like heartburn, acid reflux, and stomach ulcers by blocking the proton pump in the parietal cells of the stomach lining.
Uses & Indications
Dosage
Adults
For Erosive Esophagitis: 40 mg once daily for up to 8 weeks. For maintenance: 40 mg once daily. For Zollinger-Ellison Syndrome: Initial dose of 40 mg twice daily, adjusted as needed.
Elderly
No dosage adjustment necessary based solely on age, but consider overall health and comorbidities.
Renal_impairment
No dosage adjustment necessary for renal impairment.
How to Take
Take the tablet whole, preferably in the morning before a meal. Do not crush, chew, or split the tablet.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase (proton pump) in the secretory canaliculi of the gastric parietal cells, inhibiting gastric acid secretion. This inhibition is dose-dependent and leads to both basal and stimulated acid output reduction.
Pharmacokinetics
Onset
Antisecretory effect within 1 hour, maximum effect within 2-4 hours.
Excretion
Mainly excreted renally (approximately 80%) and partially through feces (approximately 18%).
Half life
Approximately 1 hour (terminal half-life).
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased and prolonged methotrexate levels, particularly with high-dose methotrexate.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals due to increased gastric pH. Avoid concomitant use.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of drugs whose bioavailability is pH-dependent.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and may include drowsiness, tachycardia, nausea, headache, and abdominal pain. Treatment is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in human milk, caution is advised for nursing mothers.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concurrent use with atazanavir or nelfinavir
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
Increased and prolonged methotrexate levels, particularly with high-dose methotrexate.
Atazanavir, Nelfinavir
Reduced absorption and efficacy of these antiretrovirals due to increased gastric pH. Avoid concomitant use.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of drugs whose bioavailability is pH-dependent.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms are generally mild and may include drowsiness, tachycardia, nausea, headache, and abdominal pain. Treatment is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in human milk, caution is advised for nursing mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generics available, patent expired for original compound
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated efficacy and safety in GERD, erosive esophagitis, and other acid-related disorders. Ongoing research continues to explore long-term effects and new indications.
Lab Monitoring
- Monitor magnesium levels with prolonged use (especially >1 year)
- Consider monitoring vitamin B12 levels in patients with malabsorption conditions or prolonged use
- Liver function tests in case of hepatic impairment.
Doctor Notes
- Advise patients about potential long-term risks, especially bone fractures and hypomagnesemia.
- Consider lowest effective dose and shortest duration of therapy.
- Assess for H. pylori infection in appropriate cases.
- Counsel patients on lifestyle modifications to aid treatment.
Patient Guidelines
- Take the medicine as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor, even if you feel better.
- Inform your doctor about all other medications you are taking.
- Report any unusual symptoms or severe side effects to your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantoprazole may cause dizziness or visual disturbances in some patients. If these occur, avoid driving or operating machinery.
Lifestyle Advice
- Avoid large meals before bedtime.
- Limit intake of fatty, spicy, and acidic foods.
- Avoid alcohol and smoking.
- Maintain a healthy weight.
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Global Brand Names
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