Pantac
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantac 20 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Pantac 20 mg tablet is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It treats conditions like heartburn, acid reflux, and ulcers.
Uses & Indications
Dosage
Adults
For GERD/Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. For Duodenal/Gastric Ulcers: 40 mg once daily for 2-4 weeks. For H. pylori eradication: 40 mg twice daily for 7-14 days (with antibiotics).
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is necessary for patients with impaired renal function.
How to Take
Take the tablet whole, do not crush, chew, or split. It is usually taken once daily in the morning, before a meal.
Mechanism of Action
Pantoprazole irreversibly binds to and inhibits the H+/K+ ATPase (proton pump) in the gastric parietal cells, thereby blocking the final step of acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Mainly excreted renally (about 80%) and the remainder in feces (about 20%) via biliary excretion.
Half life
Approximately 1 hour
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations reached in 2-2.5 hours. Bioavailability is about 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
Drug Interactions
Warfarin
Possible increased INR and bleeding risk; monitor closely.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses; consider temporary discontinuation of PPI.
Ketoconazole, Itraconazole, Atazanavir
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. It is excreted into breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
Drug Interactions
Warfarin
Possible increased INR and bleeding risk; monitor closely.
Methotrexate
Increased plasma levels of methotrexate, especially with high doses; consider temporary discontinuation of PPI.
Ketoconazole, Itraconazole, Atazanavir
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. It is excreted into breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, check the expiry date on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities worldwide, including FDA and DGDA
Patent Status
Generally off-patent, many generic versions available
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety for various acid-related disorders. Ongoing research continues to explore its long-term effects and new applications.
Lab Monitoring
- Monitor magnesium levels in patients on long-term therapy or with concomitant drugs that can cause hypomagnesemia. Monitor Vitamin B12 levels in prolonged use.
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Consider magnesium supplementation for patients on long-term PPI therapy, especially with diuretics.
Patient Guidelines
- Take Pantac 20 mg tablet exactly as prescribed by your doctor.
- Swallow the tablet whole with a glass of water, do not chew, crush, or break it.
- It is best to take it about 30-60 minutes before breakfast.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantac may cause dizziness or visual disturbances in some individuals. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, acidic foods, caffeine, and alcohol.
- Eat smaller, more frequent meals. Avoid eating close to bedtime.
- Elevate the head of your bed to reduce reflux symptoms.
- If you smoke, try to quit, as smoking can worsen GERD.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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