Pantac
Generic Name
Pantoprazole
Manufacturer
ACI Limited
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantac 40 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Pantac 40 mg tablet contains Pantoprazole, which is a proton pump inhibitor (PPI) used to reduce the amount of acid produced in the stomach. It is effective in treating acid-related conditions like heartburn, acid reflux, and stomach ulcers.
Uses & Indications
Dosage
Adults
Erosive Esophagitis: 40 mg once daily for up to 8 weeks. Maintenance: 40 mg once daily. Pathological Hypersecretory Conditions: Initial 40 mg twice daily, adjusted based on individual needs. Duodenal/Gastric Ulcers: 40 mg once daily, typically for 2-4 weeks. H. pylori eradication: 40 mg twice daily for 7-14 days in combination with appropriate antibiotics.
Elderly
No dosage adjustment is generally required.
Renal_impairment
No dosage adjustment is generally required for patients with renal impairment.
Hepatic_impairment
For patients with severe hepatic impairment, a maximum dose of 40 mg once daily should not be exceeded.
How to Take
Take Pantac 40 mg tablet once daily, preferably in the morning before a meal. Swallow the tablet whole with water. Do not chew or crush it.
Mechanism of Action
Pantoprazole irreversibly blocks the H+/K+-ATPase enzyme system (the proton pump) in the gastric parietal cells. This inhibition prevents the final step of gastric acid secretion, leading to a reduction in both basal and stimulated acid production.
Pharmacokinetics
Onset
Onset of acid secretion inhibition occurs within 2.5 hours, with maximum effect within 2.5 hours.
Excretion
Primarily excreted renally (approximately 80%) and the remainder in feces (approximately 20%) via biliary excretion.
Half life
Approximately 1 hour (terminal elimination half-life), but duration of acid suppression is much longer due to irreversible binding to proton pump.
Absorption
Rapidly absorbed after oral administration; absolute bioavailability is about 77%. Food may delay absorption but does not affect the overall bioavailability.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Possible increased INR and prothrombin time. Monitor closely.
Methotrexate
May increase serum levels of methotrexate, particularly high doses. Consider temporary PPI withdrawal.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption due to increased gastric pH, leading to decreased efficacy of antivirals. Avoid concomitant use.
Iron salts, Ketoconazole, Itraconazole, Erlotinib
Absorption may be decreased due to reduced gastric acidity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management should be symptomatic and supportive. Pantoprazole is not extensively removed from the circulation by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Pantoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Side Effects
Contraindications
- Known hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Possible increased INR and prothrombin time. Monitor closely.
Methotrexate
May increase serum levels of methotrexate, particularly high doses. Consider temporary PPI withdrawal.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption due to increased gastric pH, leading to decreased efficacy of antivirals. Avoid concomitant use.
Iron salts, Ketoconazole, Itraconazole, Erlotinib
Absorption may be decreased due to reduced gastric acidity.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Management should be symptomatic and supportive. Pantoprazole is not extensively removed from the circulation by hemodialysis.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Pantoprazole is excreted in human milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 to 36 months from the date of manufacture.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA/DGDA
Patent Status
Off-patent (generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pantoprazole in various acid-related disorders. Studies have shown its superiority over placebo and non-inferiority to other PPIs in healing rates and symptom relief.
Lab Monitoring
- Monitor serum magnesium levels periodically in patients expected to be on prolonged treatment or who take PPIs with other drugs that may cause hypomagnesemia.
- Monitor Vitamin B12 levels with long-term use.
- Liver function tests may be considered in patients with pre-existing hepatic impairment.
Doctor Notes
- Proton Pump Inhibitors (PPIs) should be prescribed at the lowest effective dose for the shortest duration consistent with the treatment goals.
- Re-evaluate the need for continued PPI therapy periodically, especially for long-term users.
- Consider alternative diagnoses for patients with persistent or recurring symptoms despite adequate PPI therapy.
- Be mindful of potential drug interactions, especially with drugs requiring acidic gastric pH for absorption or those metabolized by CYP2C19/3A4.
- Educate patients on potential long-term risks such as bone fractures, C. difficile infection, and B12 deficiency.
Patient Guidelines
- Take Pantac 40 mg tablet exactly as prescribed by your doctor.
- Swallow the tablet whole; do not chew, crush, or break it.
- Take it approximately 30-60 minutes before your morning meal.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
- Do not stop taking the medicine suddenly without consulting your doctor, even if you feel better.
- Seek immediate medical attention if you experience severe or persistent side effects.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantoprazole may cause dizziness, visual disturbances, or somnolence. If you experience these effects, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty, acidic foods, caffeine, and chocolate that can worsen acid reflux.
- Eat smaller, more frequent meals instead of large ones.
- Avoid lying down for at least 3 hours after eating.
- Elevate the head of your bed by 6-8 inches to help reduce nighttime reflux.
- Maintain a healthy weight, as excess weight can put pressure on your stomach and worsen symptoms.
- Reduce or quit smoking and limit alcohol consumption.
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