Panto
Generic Name
Pantoprazole
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panto 20 mg tablet | ৳ 4.00 | ৳ 40.00 |
Description
Overview of the medicine
Panto 20 mg Tablet contains pantoprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in your stomach. It is used for the treatment of acid-related diseases of the stomach and intestine.
Uses & Indications
Dosage
Adults
Usually 20 mg or 40 mg once daily, depending on the condition. For GERD, 20-40 mg once daily for 4-8 weeks. For H. pylori eradication, 40 mg twice daily for 7-14 days.
Elderly
No specific dose adjustment is usually required for elderly patients.
Renal_impairment
No dose adjustment is generally required for patients with renal impairment.
How to Take
Take the tablet orally, preferably 30-60 minutes before a meal. Swallow the tablet whole with water; do not crush or chew it.
Mechanism of Action
Pantoprazole is a substituted benzimidazole that inhibits gastric acid secretion by irreversibly blocking the H+/K+-ATPase (proton pump) in the parietal cells of the stomach. This leads to a dose-dependent reduction of both basal and stimulated acid secretion.
Pharmacokinetics
Onset
Acid-suppressive effect begins within 2.5 hours, with full effect achieved after a few days of consistent dosing.
Excretion
Mainly excreted renally (approximately 80%) as metabolites, with the remainder excreted in feces (approximately 20%).
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 2-2.5 hours. Bioavailability is approximately 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any other proton pump inhibitor or to any of the excipients.
- Severe hepatic impairment (caution).
Drug Interactions
Warfarin
May increase INR and prothrombin time, increasing risk of bleeding. Monitor INR.
Methotrexate
May increase serum levels of methotrexate, especially at high doses. Consider temporary withdrawal of PPI.
Atazanavir/Nelfinavir
Coadministration not recommended due to significantly reduced bioavailability of antiretrovirals.
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Iron salts)
Pantoprazole may decrease absorption of these drugs.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. In case of overdose, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Excreted in human milk; use with caution in breastfeeding mothers, consider the benefit/risk ratio.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any other proton pump inhibitor or to any of the excipients.
- Severe hepatic impairment (caution).
Drug Interactions
Warfarin
May increase INR and prothrombin time, increasing risk of bleeding. Monitor INR.
Methotrexate
May increase serum levels of methotrexate, especially at high doses. Consider temporary withdrawal of PPI.
Atazanavir/Nelfinavir
Coadministration not recommended due to significantly reduced bioavailability of antiretrovirals.
Drugs dependent on gastric pH for absorption (e.g., Ketoconazole, Iron salts)
Pantoprazole may decrease absorption of these drugs.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is no known specific antidote. In case of overdose, symptomatic and supportive treatment should be given.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Excreted in human milk; use with caution in breastfeeding mothers, consider the benefit/risk ratio.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Off-patent in many countries
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pantoprazole in treating various acid-related disorders. Ongoing research continues to explore its long-term effects and new indications.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or co-administration with diuretics)
- Vitamin B12 levels (with prolonged use)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Consider magnesium supplementation for patients on long-term therapy or with concomitant diuretic use.
- Advise patients on lifestyle modifications to complement therapy.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Swallow the tablet whole with water; do not chew, crush, or break it.
- Take it preferably before a meal.
- Do not stop taking the medicine suddenly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantoprazole is unlikely to affect ability to drive or use machines. However, if you experience dizziness or visual disturbances, do not drive or operate machinery.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty, acidic foods)
- Avoid alcohol and smoking
- Maintain a healthy weight
- Elevate the head of your bed
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