Panto
Generic Name
Pantoprazole 40 mg Tablet
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panto 40 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Pantoprazole 40 mg Tablet is a proton pump inhibitor used to treat conditions where there is too much acid in the stomach. It works by reducing the amount of acid produced.
Uses & Indications
Dosage
Adults
Typically 40 mg once daily for 4-8 weeks, or as directed by physician.
Elderly
No dosage adjustment generally required, but caution in severe hepatic impairment.
Renal_impairment
No dosage adjustment needed.
How to Take
Take whole with water, preferably in the morning before a meal. Do not chew or crush the tablet.
Mechanism of Action
Pantoprazole is a substituted benzimidazole that inactivates the H+/K+-ATPase (proton pump) in the parietal cells of the stomach, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Mainly renal (approx. 80%) and fecal (approx. 20%).
Half life
Approximately 1 hour (terminal half-life), but duration of acid suppression is much longer.
Absorption
Rapidly absorbed, bioavailability approximately 77%.
Metabolism
Extensively metabolized in the liver via cytochrome P450 (CYP2C19 and CYP3A4).
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Hypersensitivity to other substituted benzimidazoles
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Methotrexate
Possible increased methotrexate levels; consider temporary PPI withdrawal.
Atazanavir, Nelfinavir
Reduced absorption due to altered gastric pH; avoid co-administration.
Iron salts, ketoconazole, itraconazole
Reduced absorption of drugs requiring acidic gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild. Treatment is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Hypersensitivity to other substituted benzimidazoles
Drug Interactions
Warfarin
Increased INR/prothrombin time; monitor closely.
Methotrexate
Possible increased methotrexate levels; consider temporary PPI withdrawal.
Atazanavir, Nelfinavir
Reduced absorption due to altered gastric pH; avoid co-administration.
Iron salts, ketoconazole, itraconazole
Reduced absorption of drugs requiring acidic gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild. Treatment is symptomatic and supportive. Pantoprazole is not removed by hemodialysis.
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Excreted in breast milk, caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by FDA/DGDA
Patent Status
Generic available (original patent expired)
WHO Essential Medicine
YesClinical Trials
Extensively studied in various clinical trials demonstrating efficacy and safety in acid-related disorders.
Lab Monitoring
- Magnesium levels (with prolonged use)
- Vitamin B12 levels (with prolonged use)
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Evaluate for underlying malignancy in patients with refractory GERD symptoms.
- Monitor for signs of long-term adverse effects during extended therapy.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Do not stop taking the medicine abruptly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; avoid driving or operating machinery if affected.
Lifestyle Advice
- Avoid trigger foods like spicy, fatty, or acidic foods.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
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