Pantoprazole
Generic Name
Pantoprazole 20 mg Tablet
Manufacturer
Multiple manufacturers worldwide
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantoprazole 20 mg tablet | ৳ 5.00 | ৳ 50.00 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor (PPI) used to reduce stomach acid production. It is prescribed for conditions like gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
Typically 20 mg once daily, or 40 mg once daily for more severe conditions, usually for 4-8 weeks. For H. pylori eradication, 20 mg twice daily with antibiotics.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with impaired renal function or those on hemodialysis.
How to Take
Take orally, usually once daily in the morning, before a meal. Do not crush, chew, or break the tablet; swallow it whole.
Mechanism of Action
Pantoprazole is a proton pump inhibitor that irreversibly binds to and inhibits the H+/K+-ATPase enzyme system (the 'proton pump') in gastric parietal cells, thereby suppressing gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour (acid suppression), full effect in 2-3 days.
Excretion
Mainly excreted renally (approximately 71%) and a smaller portion via biliary excretion (approximately 18%).
Half life
Approximately 1 hour (terminal half-life), but acid suppression lasts much longer due to irreversible binding.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations occurring within 2-2.5 hours.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Potential for increased INR and bleeding.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma concentration of methotrexate.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of drugs dependent on gastric pH for absorption.
Atazanavir, Nelfinavir (and other HIV drugs)
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Symptomatic and supportive treatment is recommended. Pantoprazole is not extensively dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may pass into breast milk; caution advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, substituted benzimidazoles, or any component of the formulation.
- Concomitant use with rilpivirine-containing products.
Drug Interactions
Warfarin
Potential for increased INR and bleeding.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Increased plasma concentration of methotrexate.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption of drugs dependent on gastric pH for absorption.
Atazanavir, Nelfinavir (and other HIV drugs)
Reduced absorption due to altered gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Symptomatic and supportive treatment is recommended. Pantoprazole is not extensively dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts may pass into breast milk; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from manufacturing date.
Availability
Available in pharmacies, hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, DGDA)
Patent Status
Off-patent (generic versions available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of pantoprazole in various acid-related disorders. Ongoing research explores long-term effects and new indications.
Lab Monitoring
- Serum magnesium levels (especially with long-term use or concomitant diuretics)
- Vitamin B12 levels (with prolonged therapy)
Doctor Notes
- Prescribe for the shortest duration possible, consistent with the condition being treated.
- Consider lowest effective dose to minimize risks, especially for long-term therapy.
- Educate patients on potential long-term risks and symptoms to report.
Patient Guidelines
- Take the tablet whole, do not crush or chew.
- Take approximately 30-60 minutes before the first meal of the day.
- Do not stop treatment abruptly without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances in some patients. Patients should be advised not to drive or operate machinery if they experience these symptoms.
Lifestyle Advice
- Avoid trigger foods (spicy, fatty foods, caffeine, alcohol).
- Elevate head of bed for GERD symptoms.
- Maintain a healthy weight and avoid smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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