Pantoprazole
Generic Name
Pantoprazole 40 mg Tablet
Manufacturer
Multiple Manufacturers (Generic)
Country
Globally manufactured
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pantoprazole 40 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Pantoprazole is a proton pump inhibitor (PPI) used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus.
Uses & Indications
Dosage
Adults
GERD: 40 mg once daily for up to 8 weeks. Erosive Esophagitis: 40 mg once daily for up to 8 weeks, maintenance 20-40 mg daily. Zollinger-Ellison Syndrome: Initial 40 mg twice daily, adjusted as needed.
Elderly
No specific dose adjustment is generally required, but caution is advised in elderly patients with hepatic impairment.
Renal_impairment
No dose adjustment necessary.
How to Take
Take orally, once daily, usually in the morning before breakfast. Swallow whole; do not crush, chew, or split the tablet.
Mechanism of Action
Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+-ATPase enzyme system at the secretory surface of the gastric parietal cell. This binding leads to inhibition of both basal and stimulated gastric acid secretion.
Pharmacokinetics
Onset
Within 2.5 hours
Excretion
Mainly excreted renally (approximately 71%) and partly through biliary excretion/feces (approximately 18%).
Half life
Approximately 1 hour (terminal half-life), but duration of acid suppression is much longer.
Absorption
Rapidly absorbed after oral administration; bioavailability is about 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Known hypersensitivity to substituted benzimidazoles
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Possible increased and prolonged serum levels of methotrexate.
Atazanavir, Nelfinavir
Reduced plasma concentrations and therapeutic effect of antiretroviral drugs.
Iron Salts, Vitamin B12
Decreased absorption due to reduced gastric acidity.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
There is no known specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution in breastfeeding mothers.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Known hypersensitivity to substituted benzimidazoles
Drug Interactions
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Possible increased and prolonged serum levels of methotrexate.
Atazanavir, Nelfinavir
Reduced plasma concentrations and therapeutic effect of antiretroviral drugs.
Iron Salts, Vitamin B12
Decreased absorption due to reduced gastric acidity.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
There is no known specific antidote. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in breast milk; use with caution in breastfeeding mothers.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
FDA Approved
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established its efficacy and safety for various acid-related disorders.
Lab Monitoring
- Serum magnesium levels (especially with prolonged use or with other drugs causing hypomagnesemia)
- Vitamin B12 levels (with prolonged use)
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Evaluate need for continued PPI therapy periodically.
- Monitor for potential drug interactions, especially with clopidogrel and certain antiretrovirals.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose.
Driving Precautions
Pantoprazole generally does not impair the ability to drive or operate machinery. However, if side effects such as dizziness or visual disturbances occur, caution should be exercised.
Lifestyle Advice
- Avoid trigger foods (e.g., spicy, fatty foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Elevate the head of your bed when sleeping.
- Maintain a healthy weight.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
Other Medicines in Pantoprazole Brand
Other medicines available under the same brand name
