Panzer
Generic Name
Pantoprazole 20 mg Tablet
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panzer 20 mg tablet | ৳ 4.02 | ৳ 40.20 |
Description
Overview of the medicine
Panzer 20 mg Tablet contains Pantoprazole, a proton pump inhibitor used to reduce acid production in the stomach. It is prescribed for conditions like heartburn, acid reflux, ulcers, and Zollinger-Ellison syndrome.
Uses & Indications
Dosage
Adults
For GERD and erosive esophagitis: 20-40 mg once daily for 4-8 weeks. For ulcers: 40 mg once daily for 2-4 weeks. For Zollinger-Ellison Syndrome: 40-80 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is generally required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Take the tablet whole with a glass of water, preferably in the morning before a meal. Do not chew or crush the tablet.
Mechanism of Action
Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme (proton pump) in the gastric parietal cells, inhibiting the final step of acid secretion, thereby reducing gastric acid output.
Pharmacokinetics
Onset
2-2.5 hours
Excretion
Primarily excreted via the kidneys (approximately 80%) as metabolites, with the remainder excreted in the feces.
Half life
Approximately 1 hour (terminal elimination half-life is longer due to irreversible binding)
Absorption
Rapidly absorbed from the small intestine after oral administration. Bioavailability is approximately 77%.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, primarily by CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concomitant use with rilpivirine-containing products
Drug Interactions
Warfarin
Increased risk of bleeding due to elevated INR.
Methotrexate
Increased plasma levels of methotrexate, especially at high doses.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption and efficacy of antiretrovirals.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, and headache. Treatment is symptomatic and supportive; no specific antidote exists. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Known hypersensitivity to Pantoprazole or any component of the formulation
- Concomitant use with rilpivirine-containing products
Drug Interactions
Warfarin
Increased risk of bleeding due to elevated INR.
Methotrexate
Increased plasma levels of methotrexate, especially at high doses.
Atazanavir, Nelfinavir, Rilpivirine
Reduced absorption and efficacy of antiretrovirals.
Iron salts, Ketoconazole, Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, and headache. Treatment is symptomatic and supportive; no specific antidote exists. Hemodialysis is not effective.
Pregnancy & Lactation
Pregnancy Category B. Use only if clearly needed. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of pantoprazole in treating acid-related disorders. Studies confirm its role in healing erosive esophagitis and maintaining remission.
Lab Monitoring
- Consider magnesium levels with long-term use (≥3 months) or concomitant use with other hypomagnesemia-inducing drugs.
- INR monitoring for patients on warfarin.
- Chromogranin A (CgA) levels for neuroendocrine tumor diagnosis (can be elevated by PPIs).
Doctor Notes
- Counsel patients on potential long-term side effects and the importance of lowest effective dose for shortest duration.
- Consider screening for H. pylori before initiating long-term therapy for dyspepsia.
Patient Guidelines
- Take as directed by your doctor.
- Do not stop taking the medicine abruptly, even if symptoms improve.
- Inform your doctor about all other medications you are taking.
- Report any new or worsening symptoms.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness or visual disturbances in some individuals. If affected, avoid driving or operating machinery.
Lifestyle Advice
- Avoid trigger foods such as spicy, fatty foods, caffeine, and acidic beverages.
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed if experiencing nighttime reflux.
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Global Brand Names
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