Panzer
Generic Name
Pantoprazole 40 mg tablet
Manufacturer
Acme Laboratories Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| panzer 40 mg tablet | ৳ 6.02 | ৳ 60.20 |
Description
Overview of the medicine
Panzer 40 mg Tablet contains Pantoprazole, which is a proton pump inhibitor (PPI). It reduces the amount of acid your stomach makes, providing relief from heartburn, acid reflux, and helping to heal acid-related damage to the stomach and esophagus.
Uses & Indications
Dosage
Adults
For GERD and erosive esophagitis: 40 mg once daily for up to 8 weeks. For peptic ulcer disease: 40 mg once daily for 2-4 weeks. For Zollinger-Ellison Syndrome: Initial dose of 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is required for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment.
How to Take
Panzer 40 mg tablets should be swallowed whole with water, preferably 30-60 minutes before a meal. Do not crush or chew the tablet.
Mechanism of Action
Pantoprazole selectively blocks the H+/K+-ATPase enzyme system (the proton pump) at the secretory surface of the gastric parietal cell, thereby inhibiting the final step in gastric acid secretion.
Pharmacokinetics
Onset
Onset of acid suppression effect occurs within 2.5 hours.
Excretion
Excreted mainly via the kidneys (approximately 80%) and the remainder via the feces.
Half life
Approximately 1 hour (terminal elimination half-life), but the duration of action is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed after oral administration; bioavailability is approximately 77%. Peak plasma concentrations are reached in about 2-2.5 hours.
Metabolism
Extensively metabolized in the liver via the cytochrome P450 (CYP) system, primarily CYP2C19 and CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to significant reduction in their plasma concentrations.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
May increase methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Reduced efficacy due to decreased absorption; avoid co-administration.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. It is not known whether pantoprazole is excreted in human milk; use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation.
- Co-administration with atazanavir or nelfinavir due to significant reduction in their plasma concentrations.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Methotrexate
May increase methotrexate levels, especially with high doses.
Atazanavir/Nelfinavir
Reduced efficacy due to decreased absorption; avoid co-administration.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Experience with pantoprazole overdose is limited. Management should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if clearly needed. It is not known whether pantoprazole is excreted in human milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Pantoprazole has undergone extensive clinical trials demonstrating its efficacy and safety in treating acid-related gastrointestinal disorders, including GERD, peptic ulcers, and H. pylori eradication.
Lab Monitoring
- Serum magnesium levels (if on long-term treatment, especially with diuretics)
- Liver function tests (if liver dysfunction is suspected)
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Advise patients on lifestyle modifications to complement therapy.
- Monitor for long-term complications, especially in elderly patients or those with risk factors.
- Assess for drug interactions, particularly with warfarin, methotrexate, and antiretrovirals.
Patient Guidelines
- Take this medicine exactly as prescribed by your doctor.
- Do not crush, chew, or split the tablet; swallow it whole.
- Inform your doctor about all your medical conditions and other medications you are taking.
- If you experience severe or persistent side effects, contact your doctor immediately.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness in some individuals. If you experience dizziness, avoid driving or operating heavy machinery.
Lifestyle Advice
- Avoid foods and drinks that trigger heartburn or acid reflux (e.g., fatty foods, spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating; wait at least 2-3 hours.
- Elevate the head of your bed if you experience nocturnal reflux symptoms.
- Maintain a healthy weight.
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