Pol
Generic Name
Paracetamol
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pol 500 mg tablet | ৳ 1.20 | ৳ 12.00 |
Description
Overview of the medicine
Pol 500 mg Tablet contains Paracetamol, a widely used medication for relieving pain and reducing fever.
Uses & Indications
Dosage
Adults
500 mg to 1000 mg (1-2 tablets) every 4-6 hours as needed. Maximum 4000 mg (8 tablets) in 24 hours.
Elderly
Generally same as adults, but caution with hepatic/renal impairment. Consult doctor.
Renal_impairment
Dosage interval may need to be extended (e.g., 6-8 hours for CrCl 10-50 mL/min, 8-12 hours for CrCl <10 mL/min). Consult doctor.
How to Take
Take orally with water, with or without food. Do not exceed the recommended dose or frequency.
Mechanism of Action
Paracetamol (acetaminophen) is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis through a mechanism not fully understood, but potentially involving selective inhibition of COX-3 or modulation of the endocannabinoid system. It has weak peripheral anti-inflammatory effects.
Pharmacokinetics
Onset
30-60 minutes for analgesia, similar for antipyresis.
Excretion
Excreted mainly in the urine, predominantly as glucuronide and sulfate conjugates. Less than 5% is excreted unchanged.
Half life
1-3 hours in adults, slightly longer in neonates and patients with hepatic or renal impairment.
Absorption
Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 10-60 minutes after oral administration.
Metabolism
Primarily metabolized in the liver via glucuronidation and sulfation, and a small amount by cytochrome P450 to a highly reactive intermediate (N-acetyl-p-benzoquinone imine or NAPQI) which is rapidly detoxified by conjugation with glutathione.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity with paracetamol, even at therapeutic doses.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding, especially with prolonged use or higher doses. Regular monitoring of INR is recommended.
Other paracetamol-containing products
Increased risk of overdose and severe liver damage.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage, which may appear 24-48 hours after ingestion. Severe overdose can lead to hepatic necrosis and death. Treatment involves prompt administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during all stages of pregnancy and lactation when used at recommended doses. It is the preferred analgesic/antipyretic during pregnancy. Consult a doctor before use.
Side Effects
Contraindications
- Hypersensitivity to paracetamol or any component of the formulation.
- Severe hepatic impairment or active liver disease.
Drug Interactions
Alcohol
Chronic alcohol consumption increases the risk of hepatotoxicity with paracetamol, even at therapeutic doses.
Warfarin
May increase the anticoagulant effect of warfarin, leading to an increased risk of bleeding, especially with prolonged use or higher doses. Regular monitoring of INR is recommended.
Other paracetamol-containing products
Increased risk of overdose and severe liver damage.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, and liver damage, which may appear 24-48 hours after ingestion. Severe overdose can lead to hepatic necrosis and death. Treatment involves prompt administration of N-acetylcysteine (NAC) as an antidote.
Pregnancy & Lactation
Paracetamol is generally considered safe for use during all stages of pregnancy and lactation when used at recommended doses. It is the preferred analgesic/antipyretic during pregnancy. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 3-5 years from the date of manufacture.
Availability
Pharmacies, supermarkets, general stores
Approval Status
Approved worldwide
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied and widely used for decades. Ongoing research focuses on specific populations and potential new therapeutic uses or formulations.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in cases of suspected overdose or prolonged high-dose therapy.
- Renal function tests (creatinine, BUN) in patients with pre-existing renal impairment.
Doctor Notes
- Emphasize strict adherence to dosing limits to prevent hepatotoxicity.
- Advise patients to check other medications for paracetamol content to avoid accidental overdose.
- Consider liver function monitoring in patients with chronic alcohol use or pre-existing liver disease.
Patient Guidelines
- Do not exceed the maximum recommended dose of 4000 mg in 24 hours.
- Avoid taking other paracetamol-containing products simultaneously.
- Consult a doctor if pain or fever persists for more than a few days.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Paracetamol is generally not known to affect the ability to drive or operate machinery. However, if you experience dizziness or side effects, avoid these activities.
Lifestyle Advice
- Stay hydrated, especially when suffering from fever.
- Rest adequately to aid recovery from illness.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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