Take Ponaxen tablets orally with a full glass of water, preferably with food or milk to minimize gastrointestinal discomfort. Do not crush, chew, or break the tablet; swallow it whole.

Xenoprofen, like other NSAIDs, acts by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition leads to a reduced synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever. By blocking prostaglandin production, it reduces these symptoms.

• •Hypersensitivity to Xenoprofen, aspirin, or other NSAIDs (e.g., asthma, urticaria, allergic-type reactions)
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Severe renal or hepatic impairment
• •Severe heart failure
• •Third trimester of pregnancy
• •Coronary artery bypass graft (CABG) surgery

Store in a cool, dry place below 30°C (86°F), protected from light and moisture. Keep out of reach of children. Do not freeze.

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, dizziness, drowsiness, tinnitus. In severe cases, gastrointestinal bleeding, acute renal failure, coma, and convulsions may occur. Management involves symptomatic and supportive care. Gastric lavage and/or activated charcoal may be considered if ingestion was recent. Monitor vital signs and renal function.

Pregnancy Category C in the first two trimesters and D in the third trimester. Avoid use during the third trimester of pregnancy due to potential adverse effects on the fetal cardiovascular system (premature closure of ductus arteriosus). Use with caution during lactation; small amounts of NSAIDs may be excreted in breast milk. Consult a physician before use.