Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush or chew.

Ponaxen (Axenaprofen) works by inhibiting the activity of cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2. This inhibition leads to a reduction in the synthesis of prostaglandins, which are key mediators of pain, inflammation, and fever.

• •Hypersensitivity to Axenaprofen or other NSAIDs (e.g., aspirin, ibuprofen)
• •Active gastrointestinal bleeding or peptic ulcer disease
• •Severe heart failure
• •Third trimester of pregnancy
• •Severe renal or hepatic impairment

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms may include lethargy, drowsiness, nausea, vomiting, epigastric pain, and gastrointestinal bleeding. Severe overdose may result in hypertension, acute renal failure, respiratory depression, and coma. Management involves supportive care, gastric lavage or activated charcoal if recent ingestion, and symptomatic treatment.

Pregnancy Category C in first and second trimesters, Category D in third trimester. Avoid in late pregnancy due to potential for premature closure of the ductus arteriosus and inhibition of labor. Use with caution during lactation; small amounts may pass into breast milk.