Pregaba
Generic Name
Pregabalin
Manufacturer
Example Manufacturer (e.g., Square Pharmaceuticals Ltd.)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregaba 50 mg capsule | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Pregabalin 50 mg capsule is primarily used to treat neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial onset seizures in adults. It works by reducing abnormal electrical activity in the brain and by altering the release of certain neurotransmitters.
Uses & Indications
Dosage
Adults
Initial dose 75 mg twice daily or 50 mg three times daily, gradually increased based on response and tolerability, up to a maximum of 300 mg twice daily or 200 mg three times daily (total 600 mg/day).
Elderly
May require lower doses due to potential for decreased renal function. Dose titration should be gradual.
Renal_impairment
Dosage adjustment is necessary based on creatinine clearance. For CrCl 30-60 mL/min, 25-50 mg twice daily or 50-100 mg once daily. For CrCl <15 mL/min, 25-50 mg once daily.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system. This binding reduces the release of several neurotransmitters, including glutamate, norepinephrine, and substance P, thereby reducing neuronal excitability and pain signaling.
Pharmacokinetics
Onset
Pain relief may be noticed within 1 week for neuropathic pain; for anxiety, within 1 week.
Excretion
Primarily excreted unchanged by the kidneys.
Half life
Approximately 6.3 hours.
Absorption
Rapidly absorbed after oral administration, peak plasma concentrations typically occur within 1.5 hours.
Metabolism
Negligible metabolism in humans; approximately 98% excreted unchanged in urine.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe renal impairment (requires careful dosage adjustment).
Drug Interactions
Ethanol (alcohol)
Increases CNS depressant effects.
Opioids (e.g., oxycodone)
Increased risk of central nervous system (CNS) depression, respiratory depression, and sedation.
Benzodiazepines (e.g., lorazepam)
Potentiates CNS depressant effects, increasing risk of dizziness and drowsiness.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
- Severe renal impairment (requires careful dosage adjustment).
Drug Interactions
Ethanol (alcohol)
Increases CNS depressant effects.
Opioids (e.g., oxycodone)
Increased risk of central nervous system (CNS) depression, respiratory depression, and sedation.
Benzodiazepines (e.g., lorazepam)
Potentiates CNS depressant effects, increasing risk of dizziness and drowsiness.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and restlessness. Treatment is supportive and symptomatic; hemodialysis may be considered in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted in breast milk; caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved (e.g., FDA, DGDA)
Patent Status
Generic versions available
Clinical Trials
Extensive clinical trials have demonstrated efficacy in neuropathic pain, fibromyalgia, and as an adjunctive therapy for partial onset seizures. Ongoing research explores other potential indications.
Lab Monitoring
- Monitor renal function (creatinine clearance) in patients with kidney impairment. Periodically monitor for signs of edema and weight gain. Monitor for suicidal ideation/behavior.
Doctor Notes
- Emphasize gradual tapering to prevent withdrawal symptoms.
- Counsel patients on potential CNS depressant effects, especially with concomitant use of other CNS depressants.
- Advise patients to report any unusual swelling or allergic reactions immediately.
Patient Guidelines
- Do not stop taking pregabalin abruptly, as this can lead to withdrawal symptoms. Taper off gradually under medical supervision.
- Be aware of potential dizziness and drowsiness, especially at the start of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you.
- Report any mood changes, suicidal thoughts, or unusual behavior to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabalin can cause dizziness, drowsiness, and blurred vision, which may impair your ability to drive or operate machinery. Avoid such activities until you are certain the medicine does not affect your alertness.
Lifestyle Advice
- Avoid alcohol consumption while taking pregabalin, as it can worsen side effects like dizziness and drowsiness.
- Maintain a healthy lifestyle, including regular exercise and a balanced diet, to help manage underlying conditions.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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