Pregaba
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pregaba 75 mg capsule | ৳ 19.00 | ৳ 190.00 |
Description
Overview of the medicine
Pregabalin is an anticonvulsant and neuropathic pain agent. It is used to treat neuropathic pain, fibromyalgia, partial-onset seizures, and generalized anxiety disorder.
Uses & Indications
Dosage
Adults
Initial dose 75 mg twice daily or 50 mg three times daily (150 mg/day). May be increased to a maximum of 300 mg twice daily or 600 mg daily.
Elderly
Dose adjustment may be necessary due to age-related decrease in renal function. Start with a lower dose and titrate slowly.
Renal_impairment
Dose adjustment required based on creatinine clearance. For CrCl 30-60 mL/min: 75 mg/day in 2-3 divided doses. For CrCl 15-30 mL/min: 25-50 mg/day once daily or every other day.
How to Take
Oral administration, with or without food. Swallow the capsule whole with water.
Mechanism of Action
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, reducing the release of excitatory neurotransmitters (e.g., glutamate, norepinephrine, substance P). This leads to analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Analgesic effects may take several days to weeks to become apparent. Onset of action for GAD can be within 1 week.
Excretion
Excreted primarily unchanged in the urine (approximately 98%).
Half life
Approximately 6.3 hours.
Absorption
Rapidly and well absorbed after oral administration; bioavailability is >90% and is not affected by food.
Metabolism
Negligible hepatic metabolism in humans (<2% of a dose).
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
ACE Inhibitors
Increased risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., Opioids, Benzodiazepines, Alcohol)
May enhance the CNS depressant effects of pregabalin, leading to increased drowsiness and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic. Hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the risk to the fetus. Pregabalin is excreted in breast milk; therefore, it is not recommended during lactation.
Side Effects
Contraindications
- Hypersensitivity to pregabalin or any component of the formulation.
Drug Interactions
ACE Inhibitors
Increased risk of angioedema when co-administered with pregabalin.
CNS Depressants (e.g., Opioids, Benzodiazepines, Alcohol)
May enhance the CNS depressant effects of pregabalin, leading to increased drowsiness and sedation.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, agitation, and coma. Treatment is supportive and symptomatic. Hemodialysis may be beneficial in severe cases.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit outweighs the risk to the fetus. Pregabalin is excreted in breast milk; therefore, it is not recommended during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from manufacturing date.
Availability
Available in pharmacies
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Generic available
Clinical Trials
Pregabalin has undergone extensive clinical trials supporting its efficacy and safety for approved indications, including studies on neuropathic pain, fibromyalgia, partial-onset seizures, and GAD.
Lab Monitoring
- No routine laboratory monitoring is required. Renal function should be assessed for dose adjustment in patients with kidney impairment.
Doctor Notes
- Counsel patients on the risk of CNS depression when co-administered with other CNS depressants, including alcohol.
- Emphasize the importance of gradual tapering to prevent withdrawal symptoms. Do not discontinue abruptly.
- Monitor for signs of suicidal ideation and unusual behavioral changes, especially at the start of treatment or during dose adjustments.
Patient Guidelines
- Take exactly as prescribed by your doctor. Do not stop taking pregabalin abruptly, as this can cause withdrawal symptoms.
- Avoid alcohol and other CNS depressants while taking this medicine, as it can increase drowsiness.
- Report any unusual mood changes, suicidal thoughts, or signs of allergic reactions (e.g., swelling of face, lips, tongue) to your doctor immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Pregabalin may cause dizziness, somnolence, and blurred vision. Patients should be advised not to drive or operate complex machinery until they are reasonably certain that pregabalin does not adversely affect their ability to perform such activities.
Lifestyle Advice
- Maintain a healthy diet and exercise routine to help manage potential weight gain. Avoid activities requiring mental alertness until you know how the medicine affects you.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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