Premesis
Generic Name
Ondansetron
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| premesis 4 mg tablet | ৳ 4.50 | ৳ 45.00 |
Description
Overview of the medicine
Premesis 4 mg tablet contains Ondansetron, which is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery.
Uses & Indications
Dosage
Adults
For highly emetogenic chemotherapy: 8 mg orally 30 minutes before chemotherapy, followed by 8 mg 8 hours after the first dose, and then 8 mg twice daily for 1-2 days. For moderately emetogenic chemotherapy/radiation: 8 mg orally 1-2 hours before therapy, then 8 mg every 12 hours for 1-2 days. For PONV: 16 mg orally 1 hour before anesthesia, or 8 mg 1-2 hours before surgery.
Elderly
No specific dosage adjustment is generally required for elderly patients. However, caution should be exercised in patients over 75 years of age due to increased half-life.
Renal_impairment
No dosage adjustment is recommended for patients with renal impairment (mild to moderate). For severe renal impairment (creatinine clearance <30 mL/min), a maximum daily dose of 8 mg is recommended.
How to Take
Take the tablet whole with water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Ondansetron is a selective 5-HT3 (serotonin) receptor antagonist. It works by blocking the action of serotonin, a natural substance in the body that can cause nausea and vomiting, particularly in the chemoreceptor trigger zone and vagal afferents.
Pharmacokinetics
Onset
Within 30 minutes (oral).
Excretion
About 5% of the dose is excreted unchanged in urine, with the remainder excreted as metabolites via urine and feces.
Half life
Approximately 3-5 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are reached in about 1.5 hours.
Metabolism
Extensively metabolized in the liver by multiple cytochrome P450 enzymes (CYP2D6, CYP2C9, CYP1A2).
Side Effects
Contraindications
- •Hypersensitivity to Ondansetron or any component of the formulation.
- •Concomitant use with apomorphine due to risk of profound hypotension and loss of consciousness.
Drug Interactions
Tramadol
Reduced analgesic effect of tramadol and increased risk of serotonin syndrome.
Apomorphine
Concomitant use is contraindicated due to severe hypotension and loss of consciousness.
QT prolonging drugs
Increased risk of QT prolongation and Torsades de Pointes. Caution advised.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include visual disturbances, severe constipation, hypotension, vasovagal episodes with transient AV block, and QT interval prolongation. Treatment should be symptomatic and supportive.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of impaired fertility or harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Ondansetron is excreted in breast milk in animals; caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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