Premesis 8 mg Injection is usually given by a healthcare professional as an intravenous (IV) or intramuscular (IM) injection. The dose and frequency depend on the condition being treated.

Ondansetron works by blocking the action of serotonin (a natural substance) in the brain and gut that can cause nausea and vomiting. It selectively antagonizes 5-HT3 receptors located in the chemoreceptor trigger zone (CTZ) and peripherally on vagal nerve terminals.

• •Hypersensitivity to ondansetron or any component of the formulation.
• •Concomitant use with apomorphine due to the risk of profound hypotension and loss of consciousness.

Store below 25°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose include transient visual disturbances, severe constipation, hypotension, and vasovagal episodes with transient AV block. ECG abnormalities, including QT prolongation, have been reported. Management is symptomatic and supportive.

Pregnancy Category B. Generally avoided in the first trimester. Use with caution during pregnancy only if clearly needed and the potential benefits outweigh the risks. Ondansetron is excreted in breast milk; use with caution during lactation.