Preofloxin
Generic Name
Preofloxin
Manufacturer
Innovate Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| preofloxin 500 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Preofloxin 500 mg Tablet is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
500 mg orally once daily for 7-14 days, depending on the infection type and severity.
Elderly
No specific dose adjustment is needed based on age alone, but renal function should be assessed.
Renal_impairment
For creatinine clearance 30-50 mL/min: 500 mg every 24 hours. For creatinine clearance <30 mL/min: 250 mg every 24 hours.
How to Take
Take the tablet orally with a glass of water, with or without food. Do not chew or crush the tablet.
Mechanism of Action
Preofloxin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved within 1-2 hours.
Excretion
Primarily excreted by the kidneys (both glomerular filtration and tubular secretion).
Half life
Approximately 6-8 hours.
Absorption
Rapidly and well absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 70-80%.
Metabolism
Minimally metabolized in the liver; primarily excreted as unchanged drug.
Side Effects
Contraindications
- Hypersensitivity to preofloxin or any other fluoroquinolone.
- History of tendon disorders related to fluoroquinolone administration.
- Children and adolescents below 18 years of age (due to risk of arthropathy).
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR closely.
Corticosteroids
Increased risk of tendinitis and tendon rupture.
Antacids, Iron, Zinc, Sucralfate
May reduce preofloxin absorption. Administer preofloxin 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Monitor ECG due to potential for QT prolongation. Maintain adequate hydration.
Pregnancy & Lactation
Preofloxin should not be used during pregnancy or lactation unless the potential benefit justifies the potential risk to the fetus or infant. Animal studies have shown adverse effects on cartilage development. Consult a doctor.
Side Effects
Contraindications
- Hypersensitivity to preofloxin or any other fluoroquinolone.
- History of tendon disorders related to fluoroquinolone administration.
- Children and adolescents below 18 years of age (due to risk of arthropathy).
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and convulsive seizures.
Warfarin
May enhance the anticoagulant effect of warfarin. Monitor INR closely.
Corticosteroids
Increased risk of tendinitis and tendon rupture.
Antacids, Iron, Zinc, Sucralfate
May reduce preofloxin absorption. Administer preofloxin 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptomatic and supportive treatment should be initiated. Gastric lavage and activated charcoal may be considered. Monitor ECG due to potential for QT prolongation. Maintain adequate hydration.
Pregnancy & Lactation
Preofloxin should not be used during pregnancy or lactation unless the potential benefit justifies the potential risk to the fetus or infant. Animal studies have shown adverse effects on cartilage development. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Under Patent Protection
WHO Essential Medicine
YesClinical Trials
Phase III clinical trials completed successfully, demonstrating efficacy and safety for approved indications. Post-marketing surveillance ongoing.
Lab Monitoring
- Renal function tests (creatinine clearance) for patients with renal impairment or prolonged treatment.
- Complete blood count (CBC) during prolonged therapy.
- Liver function tests (LFTs) if liver dysfunction is suspected.
Doctor Notes
- Counsel patients on potential serious adverse effects, especially tendinopathy and peripheral neuropathy.
- Avoid co-administration with multivalent cations.
- Exercise caution in patients with known or suspected QT prolongation, uncontrolled hypokalemia or hypomagnesemia, and those receiving Class IA or Class III antiarrhythmics.
Patient Guidelines
- Complete the full course of medication, even if symptoms improve.
- Drink plenty of fluids to prevent crystallization in the urine.
- Avoid excessive exposure to direct sunlight or artificial UV light.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Preofloxin may cause dizziness, lightheadedness, or visual disturbances. Patients should assess their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Maintain good hydration throughout the treatment period.
- Avoid alcohol consumption as it may worsen some side effects.
- Inform your doctor about any pre-existing medical conditions or medications.
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Global Brand Names
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