Pretor
Generic Name
Pregabalin
Manufacturer
Eskayef Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pretor 150 mg capsule | ৳ 30.09 | ৳ 300.90 |
Description
Overview of the medicine
Pretor 150 mg Capsule contains Pregabalin, an anticonvulsant and analgesic medication. It is primarily used to treat neuropathic pain, fibromyalgia, generalized anxiety disorder, and as adjunctive therapy for partial onset seizures.
Uses & Indications
Dosage
Adults
Initial dose 150 mg/day (divided into 2-3 doses), can be increased to 300 mg/day after 1 week, and up to a maximum of 600 mg/day after another week, based on response and tolerability. Dosage varies by indication.
Elderly
Dose adjustment may be necessary in elderly patients due to reduced renal function. Start with a lower dose.
Renal_impairment
Dose must be reduced in patients with impaired renal function based on creatinine clearance. For CrCl 30-60 mL/min, maximum 300 mg/day; for CrCl 15-30 mL/min, maximum 150 mg/day; for CrCl <15 mL/min, maximum 75 mg/day.
How to Take
Pretor capsules can be taken with or without food. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.
Mechanism of Action
Pregabalin binds with high affinity to the alpha2-delta (α2-δ) subunit of voltage-gated calcium channels in the central nervous system. This binding modulates the influx of calcium, thereby reducing the release of several excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. This action contributes to its analgesic, anxiolytic, and anticonvulsant effects.
Pharmacokinetics
Onset
Onset of pain relief typically within 1 week for neuropathic pain; anxiolytic effects may be seen earlier.
Excretion
Primarily excreted unchanged in the urine. Renal clearance is directly proportional to creatinine clearance.
Half life
Approximately 6.3 hours
Absorption
Rapidly and well absorbed after oral administration, peak plasma concentrations occur within 1.5 hours. Bioavailability is ≥90% and is not affected by food.
Metabolism
Negligible systemic metabolism in humans. Less than 0.1% of the dose is metabolized.
Side Effects
Contraindications
- •Hypersensitivity to pregabalin or any component of the formulation.
- •Severe respiratory depression (especially with concomitant opioid use).
Drug Interactions
Alcohol
Potentiates the impairment of motor skill and sedation caused by pregabalin. Avoid alcohol consumption.
Opioids (e.g., oxycodone)
Increased risk of respiratory depression, sedation, and coma. Concomitant use should be with caution and at lower doses.
Benzodiazepines (e.g., lorazepam)
Additive CNS depressant effects leading to increased sedation and dizziness. Monitor patients closely.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and rarely, coma. Treatment is supportive and symptomatic, with gastric lavage or activated charcoal considered if ingestion is recent. Hemodialysis can effectively remove pregabalin from plasma.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture. Refer to the packaging for exact expiry.
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA in Bangladesh)
Patent Status
Generic available (original patent expired)
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Global Brand Names
International brand names for this medicine
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