Pretor
Generic Name
Losartan Potassium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pretor 50 mg capsule | ৳ 12.04 | ৳ 120.40 |
Description
Overview of the medicine
Losartan Potassium is an angiotensin II receptor blocker (ARB) used to treat high blood pressure, reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, and manage diabetic nephropathy in patients with type 2 diabetes and hypertension.
Uses & Indications
Dosage
Adults
For hypertension: Initial dose 50 mg once daily. The dose can be increased to 100 mg once daily or 25 mg twice daily. For stroke risk reduction or diabetic nephropathy: 50 mg once daily, may be increased to 100 mg once daily based on blood pressure response.
Elderly
No initial dosage adjustment is generally required for elderly patients, though careful monitoring is advised due to potential age-related decline in renal function.
Renal_impairment
No initial dosage adjustment is necessary for patients with mild to moderate renal impairment. For severe renal impairment (creatinine clearance <30 mL/min), a lower starting dose (e.g., 25 mg once daily) may be considered.
How to Take
Pretor-50-mg-capsule can be taken orally, with or without food. It should be taken once daily at approximately the same time each day.
Mechanism of Action
Losartan selectively blocks the binding of angiotensin II to the AT1 receptor found in many tissues, including vascular smooth muscle and the adrenal gland. This prevents the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation, reduced systemic vascular resistance, and decreased blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 6 hours, full effect may take 3-6 weeks.
Excretion
Approximately 35% of the dose is excreted in the urine and 60% in the feces (via bile), as unchanged drug and metabolites.
Half life
Parent drug: 1.5-2 hours; active metabolite (E-3174): 6-9 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 33%. Peak plasma concentrations of Losartan are reached within 1 hour, and its active metabolite (E-3174) within 3-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by cytochrome P450 enzymes (CYP2C9 and CYP3A4), to an active carboxylic acid metabolite (E-3174) and several inactive metabolites.
Side Effects
Contraindications
- •Hypersensitivity to Losartan or any component of the formulation.
- •Pregnancy (especially during the second and third trimesters, due to risk of fetal injury and death).
- •Concomitant use with Aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²).
Drug Interactions
Lithium
Concurrent use may lead to increased serum lithium concentrations and toxicity. Monitor lithium levels if co-administered.
Diuretics and other antihypertensives
Co-administration may lead to an increased hypotensive effect.
Non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors
May reduce the antihypertensive effect of Losartan and increase the risk of renal function deterioration, including possible acute renal failure, particularly in elderly, volume-depleted, or renally impaired patients.
Potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium
May lead to increases in serum potassium.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include hypotension (low blood pressure) and tachycardia (rapid heartbeat); bradycardia (slow heartbeat) may occur from parasympathetic stimulation. Management involves supportive treatment; if hypotension occurs, the patient should be placed in a supine position and intravenous saline infusion initiated. Hemodialysis is unlikely to remove Losartan or its active metabolite.
Pregnancy & Lactation
Pretor-50-mg-capsule is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal injury and death. It is not recommended during breastfeeding because of the potential for adverse effects on the nursing infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 3 years from the date of manufacture when stored under recommended conditions.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
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