Primace
Generic Name
Azithrolactin
Manufacturer
Medix Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| primace 125 mg tablet | ৳ 2.50 | ৳ 25.00 |
Description
Overview of the medicine
Primace 125 mg Tablet contains Azithrolactin, a macrolide antibiotic used to treat a variety of bacterial infections, especially in pediatric patients.
Uses & Indications
Dosage
Adults
Not the primary strength for adult use. Higher strengths (250-500 mg) are typically used for adults. If prescribed, follow physician's guidance.
Elderly
No specific dosage adjustment needed for elderly patients with normal renal and hepatic function. Consult doctor.
Children
10 mg/kg orally once daily for 3 days, or 10 mg/kg on day 1 followed by 5 mg/kg on days 2-5. Maximum single dose: 500 mg.
Renal_impairment
No dosage adjustment required for mild to moderate renal impairment (creatinine clearance > 10 mL/min). Use with caution in severe impairment.
Hepatic_impairment
Use with caution in severe hepatic impairment, as Azithrolactin is primarily eliminated by the liver; dosage adjustment may be needed.
How to Take
Take orally, with or without food. To minimize gastrointestinal upset, it can be taken with food. Follow your doctor's instructions regarding the timing of doses.
Mechanism of Action
Azithrolactin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide bonds and growth of bacteria.
Pharmacokinetics
Onset
Antibacterial effects usually begin within 1-2 hours of administration.
Excretion
Mainly excreted unchanged in bile, with a small amount excreted via urine (approximately 6% of the dose).
Half life
The terminal elimination half-life is approximately 68 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%. Peak plasma concentrations typically reached within 2-3 hours.
Metabolism
Primarily hepatic, with extensive first-pass metabolism, forming inactive metabolites.
Side Effects
Contraindications
- •Known hypersensitivity to azithrolactin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
- •History of cholestatic jaundice/hepatic dysfunction associated with prior azithrolactin use.
Drug Interactions
Digoxin
May increase serum digoxin levels. Monitor digoxin concentrations.
Warfarin
May increase the anticoagulant effect of warfarin. Monitor INR closely.
QT prolonging drugs
Increased risk of QT interval prolongation and torsades de pointes. Co-administration with other QT prolonging drugs (e.g., Class IA and III antiarrhythmics, cisapride, terfenadine) is not recommended.
Antacids (containing aluminum or magnesium)
Decrease peak plasma concentrations of azithrolactin. Administer azithrolactin at least 1 hour before or 2 hours after antacids.
Storage
Store below 30°C in a cool, dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Gastric lavage and general supportive measures are recommended. Hemodialysis is not effective for removal.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus. However, there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed after careful risk-benefit assessment. Excreted in breast milk; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Generic available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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