Priocin
Generic Name
Clindamycin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| priocin 500 mg tablet | ৳ 7.00 | ৳ 70.00 |
Description
Overview of the medicine
Priocin 500 mg Tablet contains Clindamycin, a lincosamide antibiotic used to treat various serious bacterial infections including those of the skin, soft tissue, respiratory tract, gynecological organs, and intra-abdominal areas. It works by stopping the growth of bacteria.
Uses & Indications
Dosage
Adults
For serious infections, 150-300 mg every 6 hours. For more severe infections, 300-450 mg every 6 hours. A 500 mg tablet might be prescribed for severe cases, often once or twice daily depending on infection and physician's assessment.
Elderly
No specific dosage adjustment is required based solely on age, but renal and hepatic function should be monitored.
Renal_impairment
Dose adjustment is generally not necessary in mild to moderate renal impairment. In severe renal impairment, consider dose reduction or increased dosing interval.
How to Take
Take the tablet orally with a full glass of water, with or without food, to prevent esophageal irritation. Do not lie down for at least 30 minutes after taking the medicine.
Mechanism of Action
Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide chain elongation. This action leads to bacteriostatic effects.
Pharmacokinetics
Onset
Within 1 hour.
Excretion
Approximately 10% of the dose is excreted in urine and 4% in feces as active drug or metabolites. The remainder is eliminated as inactive metabolites.
Half life
Approximately 2-3 hours in adults with normal renal and hepatic function. May be prolonged in patients with severe hepatic or renal impairment.
Absorption
Rapidly and almost completely absorbed (about 90%) after oral administration. Peak plasma concentrations are achieved in about 45-60 minutes.
Metabolism
Extensively metabolized in the liver to active and inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to clindamycin, lincomycin, or any component of the formulation.
- History of C. difficile-associated diarrhea (CDAD) or other severe gastrointestinal disease.
- Infants younger than one month of age.
Drug Interactions
Erythromycin
Antagonistic effect; do not administer concurrently.
Kaolin-pectin antidiarrheals
May reduce the absorption of oral clindamycin.
Neuromuscular blocking agents
May enhance the neuromuscular blocking effects, leading to prolonged muscle paralysis.
Warfarin and other vitamin K antagonists
May increase INR and risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek emergency medical attention. Treatment is primarily supportive; hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant women have not shown an increased risk of fetal abnormalities. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; therefore, exercise caution when administering to a nursing mother. Monitor breastfed infants for diarrhea or rash.
Side Effects
Contraindications
- Hypersensitivity to clindamycin, lincomycin, or any component of the formulation.
- History of C. difficile-associated diarrhea (CDAD) or other severe gastrointestinal disease.
- Infants younger than one month of age.
Drug Interactions
Erythromycin
Antagonistic effect; do not administer concurrently.
Kaolin-pectin antidiarrheals
May reduce the absorption of oral clindamycin.
Neuromuscular blocking agents
May enhance the neuromuscular blocking effects, leading to prolonged muscle paralysis.
Warfarin and other vitamin K antagonists
May increase INR and risk of bleeding.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
In case of overdose, seek emergency medical attention. Treatment is primarily supportive; hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.
Pregnancy & Lactation
Pregnancy Category B. Studies in pregnant women have not shown an increased risk of fetal abnormalities. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; therefore, exercise caution when administering to a nursing mother. Monitor breastfed infants for diarrhea or rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, specific expiry date mentioned on packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Clindamycin is a well-established antibiotic with extensive clinical trial data supporting its efficacy and safety across various indications. Ongoing research may explore new applications or formulations.
Lab Monitoring
- Periodic liver and kidney function tests are recommended during prolonged therapy.
- Complete blood count (CBC) should be performed periodically.
Doctor Notes
- Prioritize careful patient selection to avoid unnecessary use and mitigate the risk of C. difficile infection.
- Educate patients on the symptoms of CDAD and advise immediate reporting if they occur.
- Monitor liver and renal function, especially in patients on prolonged therapy or with pre-existing conditions.
Patient Guidelines
- Complete the full course of treatment as prescribed by your doctor, even if symptoms improve.
- Report any severe or persistent diarrhea to your doctor immediately.
- Take each dose with a full glass of water to help prevent esophageal irritation.
- Do not skip doses or stop taking the medicine without consulting your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Clindamycin is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or other adverse effects that impair your concentration, avoid driving.
Lifestyle Advice
- Maintain good hygiene to prevent further spread of infection.
- Stay well-hydrated, especially if experiencing diarrhea.
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