Prioxim
Generic Name
Cefixime
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| prioxim 200 mg tablet | ৳ 40.00 | ৳ 160.00 |
Description
Overview of the medicine
Prioxim 200 mg Tablet contains Cefixime, a third-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections affecting the respiratory tract, urinary tract, and ears.
Uses & Indications
Dosage
Adults
Typically 200 mg once daily or 100 mg twice daily for 7-14 days depending on infection severity. For uncomplicated gonorrhea, a single oral dose of 400 mg.
Elderly
No dose adjustment generally required unless renal function is severely impaired.
Renal_impairment
For creatinine clearance < 30 mL/min, the dose should be reduced to 100 mg once daily.
How to Take
Prioxim 200 mg Tablet can be taken with or without food. To minimize potential gastrointestinal upset, it may be taken with food. It is crucial to complete the entire prescribed course.
Mechanism of Action
Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, thereby preventing the cross-linking of peptidoglycan units, which leads to cell lysis and bacterial cell death.
Pharmacokinetics
Onset
Peak plasma concentrations are achieved 2-6 hours after administration.
Excretion
Mainly excreted by the kidneys (approximately 50% unchanged in urine) and some biliary excretion.
Half life
About 3-4 hours.
Absorption
Approximately 30-50% absorbed from the gastrointestinal tract; absorption is not significantly affected by food, but may be slightly increased.
Metabolism
Not extensively metabolized in the body; primarily excreted unchanged.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- Known hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and international normalized ratio (INR), requiring close monitoring.
Carbamazepine
Concomitant use may increase carbamazepine plasma levels.
Aminoglycosides
Increased risk of nephrotoxicity with concurrent use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise using alternative birth control.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote exists. Management should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Cefixime is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no risk, but human data is limited. Use only if clearly needed. Excreted in low concentrations in breast milk; generally considered safe, but monitor infant for potential adverse effects like diarrhea or candidiasis.
Side Effects
Contraindications
- Known hypersensitivity to cefixime or any other cephalosporin antibiotics
- Known hypersensitivity to penicillin (due to potential cross-reactivity)
Drug Interactions
Warfarin
May increase prothrombin time (PT) and international normalized ratio (INR), requiring close monitoring.
Carbamazepine
Concomitant use may increase carbamazepine plasma levels.
Aminoglycosides
Increased risk of nephrotoxicity with concurrent use.
Oral Contraceptives
May reduce the efficacy of oral contraceptives; advise using alternative birth control.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
No specific antidote exists. Management should be symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Cefixime is not effectively removed by hemodialysis or peritoneal dialysis.
Pregnancy & Lactation
Pregnancy Category B. Animal studies show no risk, but human data is limited. Use only if clearly needed. Excreted in low concentrations in breast milk; generally considered safe, but monitor infant for potential adverse effects like diarrhea or candidiasis.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by major health authorities globally (e.g., FDA, DGDA)
Patent Status
Generic available; original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of cefixime for various bacterial infections. Ongoing post-marketing surveillance and studies continue to monitor its profile.
Lab Monitoring
- Renal function (especially in prolonged therapy or renal impairment)
- Complete Blood Count (CBC) in prolonged therapy
- Liver function tests (LFTs) if abnormalities are suspected or with prolonged use
Doctor Notes
- Prescribe with caution in patients with a history of severe penicillin allergy due to potential cross-reactivity.
- Consider renal function adjustment in elderly patients and those with kidney impairment.
- Emphasize to patients the importance of completing the full course to minimize resistance development.
Patient Guidelines
- Take Prioxim 200 mg Tablet exactly as prescribed by your doctor.
- Complete the full course of antibiotics, even if you start feeling better, to prevent the infection from returning and to avoid antibiotic resistance.
- Do not share this medicine with others, even if they have similar symptoms.
- Inform your doctor about any allergies you have or any other medications you are currently taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Cefixime may cause dizziness in some individuals. If you experience dizziness, blurred vision, or confusion, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent future infections.
- Drink plenty of fluids while on antibiotic therapy.
- Avoid self-medication and always consult a doctor for infections.
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