Pro-Medrol
Generic Name
Methylprednisolone Sodium Succinate
Manufacturer
Pfizer Inc.
Country
USA
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| pro medrol 500 mg injection | ৳ 600.00 | N/A |
Description
Overview of the medicine
Pro-Medrol 500 mg Injection contains Methylprednisolone Sodium Succinate, a potent synthetic glucocorticoid. It is used for its strong anti-inflammatory and immunosuppressive properties in various conditions where rapid and intensive corticosteroid action is required.
Uses & Indications
Dosage
Adults
Dosage varies greatly depending on the condition and patient response. For severe acute conditions (e.g., pulse therapy in multiple sclerosis, severe lupus nephritis), typical dose might be 500 mg to 1000 mg IV once daily for 3-5 days. For other conditions, initial doses range from 10 mg to 250 mg IV/IM, then adjusted as needed.
Elderly
No specific dose adjustment for elderly, but caution is advised due to increased risk of side effects (e.g., osteoporosis, fluid retention).
Renal_impairment
No specific dose adjustment required for renal impairment, as methylprednisolone is primarily metabolized by the liver.
How to Take
For intravenous (IV) administration, it should be reconstituted with the provided diluent and administered slowly over several minutes (e.g., 500 mg over at least 30 minutes). For intramuscular (IM) administration, it should be injected deep into a large muscle mass after reconstitution.
Mechanism of Action
Methylprednisolone acts by binding to specific glucocorticoid receptors in the cytoplasm, leading to a complex cascade of events that alter gene expression. This results in the inhibition of inflammatory mediators, suppression of immune responses, and stabilization of cell membranes, ultimately reducing inflammation and immune activity.
Pharmacokinetics
Onset
Within minutes to hours depending on route and condition. Peak effect usually within 1-2 hours after IV administration.
Excretion
Excreted mainly in the urine as inactive metabolites.
Half life
Plasma half-life is approximately 2-3 hours. Biological half-life (duration of action) is 18-36 hours.
Absorption
Rapidly and completely absorbed after intravenous (IV) administration. Intramuscular (IM) absorption is also good.
Metabolism
Primarily hepatic, largely by the CYP3A4 enzyme.
Side Effects
Contraindications
- •Systemic fungal infections
- •Known hypersensitivity to methylprednisolone or any component of the formulation
- •Administration of live or live-attenuated vaccines to patients receiving immunosuppressive doses of corticosteroids
Drug Interactions
NSAIDs
Increased risk of gastrointestinal adverse effects and ulceration.
Cholestyramine
May decrease absorption of methylprednisolone.
Antidiabetic agents
May increase blood glucose, requiring dose adjustment of antidiabetic drugs.
Anticoagulants (e.g., Warfarin)
May potentiate or diminish anticoagulant effects; monitor INR.
Diuretics (e.g., Thiazides, Loop diuretics)
Increased potassium loss.
CYP3A4 Inducers (e.g., Rifampin, Phenytoin, Barbiturates)
May decrease methylprednisolone plasma concentrations and efficacy.
CYP3A4 Inhibitors (e.g., Ketoconazole, Erythromycin, Grapefruit juice)
May increase methylprednisolone plasma concentrations and risk of adverse effects.
Storage
Store unreconstituted powder at controlled room temperature (20°C to 25°C), excursions permitted to 15°C to 30°C. Protect from light. Do not freeze. Reconstituted solution should be used within 48 hours if refrigerated (2°C to 8°C).
Overdose
Acute overdose is rare and generally not life-threatening. Symptoms may include fluid retention, hypertension, and hyperglycemia. Treatment is primarily supportive and symptomatic. Chronic overdose can lead to Cushing's syndrome, requiring gradual dose reduction.
Pregnancy & Lactation
Pregnancy Category C. Corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Methylprednisolone is excreted in breast milk; caution is advised when administered to a nursing mother, and infants should be monitored for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Refer to the expiry date printed on the packaging and vial label. Typically, 2-3 years from the date of manufacture. Reconstituted solution should be used promptly.
Availability
Hospitals, retail pharmacies
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
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Global Brand Names
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