Probet
Generic Name
Betamethasone Valerate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| probet 005 cream | ৳ 45.00 | N/A |
Description
Overview of the medicine
Probet is a topical corticosteroid containing Betamethasone Valerate, used for treating various inflammatory skin conditions.
Uses & Indications
Dosage
Adults
Apply a thin film to the affected skin area once or twice daily. Do not use for more than 2-4 weeks without medical review.
Elderly
Use with caution, considering increased skin fragility and potential for systemic absorption.
Renal_impairment
No specific dosage adjustment required for topical application.
How to Take
For external use only. Apply a thin layer to the affected area and rub in gently. Wash hands after application.
Mechanism of Action
Betamethasone Valerate acts as an anti-inflammatory and vasoconstrictive agent. It induces phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Pharmacokinetics
Onset
Relief of symptoms can be observed within a few days of starting treatment.
Excretion
Mainly through the kidneys, with some biliary excretion.
Half life
Not well-defined for topical use due to low systemic absorption and local action, but absorbed corticosteroid is metabolized by the liver.
Absorption
Systemic absorption varies depending on the integrity of the skin barrier, the vehicle, and the use of occlusive dressings. Absorption is higher in areas with thin skin (e.g., face, scrotum) or damaged skin.
Metabolism
Primarily in the liver.
Side Effects
Contraindications
- Untreated cutaneous infections (viral, bacterial, fungal)
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Pruritus without inflammation
- Children under 1 year
Drug Interactions
Other Corticosteroids
Concurrent use may increase systemic effects due to absorption.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Chronic overdose or misuse may lead to systemic effects of hypercorticism, such as Cushing's syndrome, or local adverse effects like skin atrophy. Treatment is symptomatic.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Side Effects
Contraindications
- Untreated cutaneous infections (viral, bacterial, fungal)
- Acne vulgaris
- Rosacea
- Perioral dermatitis
- Pruritus without inflammation
- Children under 1 year
Drug Interactions
Other Corticosteroids
Concurrent use may increase systemic effects due to absorption.
Storage
Store below 30°C. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Chronic overdose or misuse may lead to systemic effects of hypercorticism, such as Cushing's syndrome, or local adverse effects like skin atrophy. Treatment is symptomatic.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit justifies the potential risk to the fetus/infant. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Well-established and widely studied. No recent novel trials for its basic efficacy.
Doctor Notes
- Advise patients on appropriate quantity and duration of use to minimize local and systemic side effects.
- Educate on proper application technique.
- Consider step-down therapy or intermittent use for chronic conditions.
Patient Guidelines
- Use exactly as directed by your doctor.
- Do not apply to the face, groin, or armpits unless specifically directed.
- Avoid contact with eyes.
- Do not use for longer than prescribed.
- Do not cover the treated area with bandages or other dressings unless advised by your doctor.
- Inform your doctor if your condition worsens or does not improve after 2 weeks of treatment.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose.
Driving Precautions
No known effects on ability to drive or operate machinery.
Lifestyle Advice
- Keep the skin moisturized to prevent dryness.
- Avoid irritants that may worsen your skin condition.
- Wear loose, cotton clothing to reduce irritation.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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